The solid effect of dynamic nuclear polarization in liquids - accounting for -tensor anisotropy at high magnetic fields.

In spite of its name, the solid effect of dynamic nuclear polarization (DNP) is also operative in viscous liquids, where the dipolar interaction between the polarized nuclear spins and the polarizing electrons is not completely averaged out by molecular diffusion on the timescale of the electronic spin-spin relaxation time. Under such slow-motional conditions, it is likely that the tumbling of the polarizing agent is similarly too slow to efficiently average the anisotropies of its magnetic tensors on the timescale of the electronic . Here we extend our previous analysis of the solid effect in liquids to account for the effect of -tensor anisotropy at high magnetic fields.

C Hyperpolarization of Viscous Liquids by Transfer of Solid-Effect H Dynamic Nuclear Polarization at High Magnetic Field.

Dynamic nuclear polarization (DNP) is routinely used as a method for increasing the sensitivity to nuclear magnetic resonance (NMR). Recently, high-field solid-effect DNP in viscous liquids on H nuclei was demonstrated using narrow-line polarizing agents. Here we expand the applicability of DNP in viscous media to C nuclei.

Rhodium(III)-catalyzed oxidative cross-coupling of benzoxazinones with styrenes C-H activation.

Vinylarenes represent an important class of core skeleton embedded in natural products, organic materials, and pharmaceutical molecules. Therefore, numerous efforts have been devoted to developing efficient methods for their preparation. Among them, transition-metal-catalyzed oxidative coupling of arenes and alkenes has proved to be a powerful method due to its high atom and step economy.

A triple resonance (e, H, C) probehead for liquid-state DNP experiments at 9.4 Tesla.

In DNP experiments, NMR signal intensity is increased by transferring the much larger electron spin polarization to nuclear spins via microwave irradiation. Here we describe the design and performance of a probehead that makes it possible to perform Overhauser DNP experiments at H and C in liquid samples with a volume of up to 100 nl. We demonstrate on a C-labeled sodium pyruvate sample in water that proton decoupling under DNP conditions is possible with this new triple-resonance DNP probehead.

Solid-like Dynamic Nuclear Polarization Observed in the Fluid Phase of Lipid Bilayers at 9.4 T.

Dynamic nuclear polarization (DNP) is a powerful method to enhance NMR sensitivity. Much progress has been achieved recently to optimize DNP performance at high magnetic fields in solid-state samples, mostly by utilizing the solid or the cross effect. In liquids, only the Overhauser mechanism is active, which exhibits a DNP field profile matching the EPR line shape of the radical, distinguishable from other DNP mechanisms.

Room-temperature dynamic nuclear polarization enhanced NMR spectroscopy of small biological molecules in water.

Nuclear magnetic resonance (NMR) spectroscopy is a powerful and popular technique for probing the molecular structures, dynamics and chemical properties. However the conventional NMR spectroscopy is bottlenecked by its low sensitivity. Dynamic nuclear polarization (DNP) boosts NMR sensitivity by orders of magnitude and resolves this limitation.