Publications by authors named "Dangmurenjiafu Geng"
Article Synopsis
- The study investigates the role of metabotropic glutamate receptor 4 (mGlu4) in glioma, finding that lower expression levels are linked to worse patient outcomes.
- Utilizing RNA-sequencing data from multiple cancer databases, researchers identified key factors like DNA methylation and specific microRNAs that regulate GRM4 expression.
- Results indicate that reduced GRM4 expression correlates with shorter overall survival, highlighting its potential as a prognostic biomarker for glioma patients.
Article Synopsis
- The study analyzes clinical and epidemiological data of CNS tumors in Uyghur children from a major hospital in Xinjiang over a 9-year period (2013-2021).
- A total of 243 children (ages 0-17) were examined, with findings indicating that 59.26% had supratentorial tumors and 53.09% were low-grade tumors, predominantly affecting rural children.
- The research revealed a male-to-female ratio of 1.43:1 and identified a peak incidence age between 6 to 8 years, reflecting specific patterns of CNS tumors in this population.
Background: To explore central nervous system (CNS) involvement in this disease, from the perspectives of diagnosis, treatment, and misdiagnosis METHODS: Twenty-eight patients with CNS echinococcosis were included in this retrospective study, including 18 males (64.3%) and 10 (35.7%) females.
View Article and Find Full Text PDFIntracranial aneurysm (IA) is a disease resulted from weak brain control, characterized by local expansion or dilation of brain artery. This study aimed to construct a gene co-expression network by Weighted Gene Correlation Network Analysis (WGCNA) to explore the potential key pathways and genes for the development of IA. Six IA-related gene expression data sets were downloaded from the Gene Expression Omnibus (GEO) database for identifying differentially expressed genes (DEGs).
View Article and Find Full Text PDFTo explore the effect of CtBP-Interacting protein (CtIP) on oxidative damage of cerebral endothelia cells and its mechanism. Cerebral endothelia cells were stimulated by TBHP to induce oxidative damage. The cell line of CtIP gene were prepared by over-expression and interfering lentivirus technology.
View Article and Find Full Text PDFObjective: Glioblastomais is one of the main universal, primary brain cancers, in adults, that has an extremely poor clinical prognosis and a median living period of 12-15 months, accounting for nearly 3-4% of all cancer-related deaths. MicroRNAs (miRNAs) play key roles in cancer pathogenesis by binding the specific and complementary sequences of the 3'UTR of target mRNAs to regulate protein synthesis. Therefore, recognizing functional miRNAs and the fundamental molecular mechanisms will offer novel evidences for the progress of targeted malignancy interferences.
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- Higher serum adiponectin levels in patients with ischemic stroke were found to correlate with increased stroke severity and poorer outcomes.
- In a study involving 227 first-ever ischemic stroke patients, adiponectin levels on admission were significantly higher compared to healthy controls, with increased risks of mortality and poor functional prognosis.
- The findings suggest that adiponectin might be an important independent predictor for stroke outcomes, indicating potential clinical significance despite previous controversies surrounding its role in stroke pathology.
Article Synopsis
- The study investigated the effects of poly-arginine R18 on neurocyte cell growth through autophagy in the context of traumatic brain injury (TBI).
- It found that R18 treatment reduced neurocyte apoptosis and promoted cell growth, as evidenced by increased levels of autophagy-related proteins LC3 and Beclin-1.
- The research suggests that poly-arginine R18 could be a promising therapeutic target for enhancing recovery in TBI by activating autophagy.
Article Synopsis
- The study investigates the factors influencing the extent of resection (EOR) in patients with large and giant pituitary adenomas undergoing endoscopic surgery, highlighting a need for better understanding of tumor characteristics that affect outcomes.* -
- Twenty-eight patients were analyzed using MRI to assess pre- and postoperative tumor volumes and related characteristics, revealing significant differences between calculated and measured volumes, especially for larger tumors.* -
- Findings suggest that volumetric analysis is more effective than traditional 2-dimensional methods for sizing pituitary tumors, with certain features like large cysts and softer tumor consistency being linked to better EOR outcomes.*
BACKGROUND This study investigated the mechanism underlying the activating mutation of SHP-2 in promoting malignant biological behaviors of glioma cells. MATERIAL AND METHODS The SHP-2 empty plasmid pcDNA3.1 and SHP-2 activating mutation plasmid pcDNA3.
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- Cerebral vasospasm (CVS) is a significant complication following aneurysmal subarachnoid hemorrhage (aSAH), leading to increased mortality and poor recovery, with limited data on its incidence in Chinese patients.
- A study of 343 aSAH patients revealed that 53.1% developed angiographic vasospasm (AV), 28.9% developed symptomatic vasospasm (SV), and 25.4% suffered cerebral infarction, with hypertension and poor clinical grades noted as main risk factors.
- Ethnic background influenced outcomes, as patients from minority groups were less likely to experience CVS complications compared to Han ethnic group patients, while age, leukocyte
The purpose of this study was to investigate the expression of microRNA-106b (miR-106b) and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in pituitary tumor and to confirm whether miR-106b promotes proliferation and invasion of pituitary tumor cells through the PI3K/AKT signaling pathway by targeted regulation of PTEN expression, and thereby to find new targets for the treatment of pituitary tumor. Fifty-five cases of pituitary tumor tissue samples were collected, including 29 cases of invasive pituitary tumor, non-invasive 26 cases, and 8 normal pituitaries. The expression level of miR-106b in pituitary tumor tissue was detected by quantitative real-time PCR, and the expression of PTEN protein was detected by immunohistochemistry.
View Article and Find Full Text PDFAim: This study aimed to investigate the operative procedure for neuroendoscope-assisted microscopic resection of petroclival meningioma to improve prognosis.
Material And Methods: Twelve patients with petroclival meningioma who had undergone neuroendoscope-assisted microscopic resection at the Department of Neurosurgery, First Affiliated Hospital of Xinjiang Medical University were selected. In addition, 12 patients with petroclival meningioma who had undergone microscopic surgery were used as control.
Article Synopsis
- The study examined how the timing of endoscopic third ventriculostomy (ETV) affects success rates and neurodevelopmental outcomes in children with congenital obstructive hydrocephalus, dividing 63 children into early (⩽6 months), midterm (6-12 months), and late (>12 months) ETV groups.
- Early ETV had a low success rate of only 20.8%, while midterm and late ETV showed significantly higher success rates of 55% and 73.7%, respectively, with late ETV yielding the best post-operative developmental improvements.
- Despite these improvements, none of the children achieved normal functioning or mild neurodevelopmental disabilities, indicating that while timing matters for ETV efficacy
Background: Echinococcosis is still endemic in many countries, including China, where it is especially prevalent in the northwest. The aim of this study was to enrich the international literature about the treatment of intracranial hydatid cysts.
Methods: We retrospectively reviewed the clinical features, radiological manifestations, and surgical outcome of 97 patients with intracranial hydatid cysts, who received surgical treatment at the Neurosurgical Department of First Affiliated Hospital of Xinjiang Medical University from 1985 to 2010 and followed up the patient via sending a questionnaire or telephone contact.