Atractylodes macrocephala Rhizomes Contain Anti-inflammatory Sesquiterpenes.

Two new compounds, named eudesm-4(15),7-diene-3α,9β,11-triol (1) and eudesm-4(15),7-diene-1β,3α,9β,11-tetraol (2) together with three known sesquiterpene lactones (1S,5R,7R,10R)-secoatractylolactone (3), (1S,5R,7R,10R)-secoatractylolactone-11-O-β-D-glucopyranoside (4) atractylenolide III (5) were isolated from the rhizomes of Atractylodes macrocephala. Their structures were elucidated by using one-dimensional (1D) and 2D-NMR spectra and high resolution electrospray ionization (HR-ESI)-MS data. Compound 5 exhibited the most active anti-inflammatory activity with IC values of 27.

Essential Oils from Vietnamese Asteraceae for Environmentally Friendly Control of Mosquitoes.

Mosquitoes, in addition to being a biting nuisance, are vectors of several pathogenic viruses and parasites. As a continuation of our work identifying abundant and/or invasive plant species in Vietnam for use as ecologically friendly pesticidal agents, we obtained the essential oils of , , , , and ; analyzed the essential oils using gas chromatographic techniques; and screened the essential oils for mosquito larvicidal activity against and . The most active larvicidal essential oils were , which was rich in thymohydroquinone dimethyl ether (29.

Undescribed chalcone and stilbene constituents from and their anti-inflammatory effect.

The chemical composition and anti-inflammatory activity of the endemic were investigated for the first time in this study. A phytochemical fractionation of the methanol extract of resulted in the isolation of a new stilbene (bavienside A) and two new chalcone glycosides (baviensides B and C, ). Their structures were elucidated via the interpretation of NMR and HRESIMS spectroscopic data.

Essential Oil Compositions of Three Invasive Species Collected in Vietnam and Their Larvicidal Activities against , , and .

Mosquito-borne infectious diseases are a persistent problem in tropical regions of the world, including Southeast Asia. Vector control has relied principally on synthetic insecticides, but these have detrimental environmental effects and there is an increasing demand for plant-based agents to control insect pests. Invasive weedy plant species may be able to serve as readily available sources of essential oils, some of which may be useful as larvicidal agents for control of mosquito populations.

Pro-apoptoticeffect of diterpenoids from on acute myeloid leukemia cells.

Previously, we isolated four known diterpenoids, -communic acid (), 13-oxo-15,16-dinor-labda-8(17), 11-diene-19-oic acid (), 3-hydroxytotarol (), and totarolone () from leaves. Further study demonstrated the antiproliferative activity of all four compounds in acute myeloid leukemia (OCI-AML) cells due to impaired cell cycle progression. Interestingly, 3-hydroxytotarol () had very powerful bioactivity at low concentrations (5 µg/mL).

Antioxidant, Xanthine Oxidase, α-Amylase and α-Glucosidase Inhibitory Activities of Bioactive Compounds from L. Root.

The root of L. has been shown to possess anti-gout and anti-diabetic properties, but the compounds responsible for these pharmaceutical effects have not yet been reported. In this study, we aimed to isolate and purify active components from the root of , and to evaluate their anti-radical, anti-gout and anti-diabetic capacities.

Anti-proliferative diterpenes from .

A new diterpene, cassipouryl hexadecanoate (), in addition to the cassipourol () and four terpenes () were isolated from the twigs and leaves of (Blume) de Laub. The structures of the two monocyclic diterpenes (, ), were elucidated on the basic of 1D and 2D NMR spectroscopic data and compared with the literature. These two monocyclic diterpenes (, ) were tested for their anti-proliferative activity on acute myeloid leukemia (OCI-AML) cells.

20-Hydroxyecdysone from Dacrycarpus imbricatus bark inhibits the proliferation of acute myeloid leukemia cells.

Objective: To investigate the anti-proliferative effects of 20-hydroxyecdysone isolated from the bark of Dacrycarpus imbricatus (Blume) de Laub.

Methods: Column chromatography was used for isolation of compounds from plant material. The structure of the isolated compound was identified by mass spectrometry and nuclear magnetic resonance techniques, including HSQC, HMBC, NOE-difference experiments.