Publications by authors named "Dang Trung Nghia Ho"
Article Synopsis
- Mycobacterium tuberculosis, which causes tuberculosis (TB), can affect various organs, including the brain, leading to a serious condition called TB meningitis (TBM), yet the immune mechanisms behind these differences in disease presentation are not fully understood.
- Research has shifted focus from T cell responses to the role of antibodies in controlling M. tuberculosis, particularly looking at how these antibodies respond differently in the lungs versus the brain.
- Using an advanced serology technique, the study analyzed antibody responses in TBM patients compared to those with pulmonary TB, revealing distinct profiles in the cerebrospinal fluid that highlight a unique immune response in TBM, potentially serving as markers for disease severity and prognosis.
An estimated 73% of emerging infections are zoonotic in origin, with animal contact and encroachment on their habitats increasing the risk of spill-over events. In Vietnam, close exposure to a wide range of animals and animal products can lead to acquisition of zoonotic pathogens, a number of which cause central nervous system (CNS) infections. However, studies show the aetiology of CNS infections remains unknown in around half of cases.
View Article and Find Full Text PDFThe ongoing coronavirus disease 2019 (COVID-19) pandemic emphasizes the need to actively study the virome of unexplained respiratory diseases. We performed viral metagenomic next-generation sequencing (mNGS) analysis of 91 nasal-throat swabs from individuals working with animals and with acute respiratory diseases. Fifteen virus RT-PCR-positive samples were included as controls, while the other 76 samples were RT-PCR negative for a wide panel of respiratory pathogens.
View Article and Find Full Text PDFEvaluation of the Luminex xTAG Respiratory Viral Panel FAST v2 assay for detection of multiple respiratory viral pathogens in nasal and throat swabs in Vietnam.
Wellcome Open Res
September 2017
Background: Acute respiratory infections (ARI) are among the leading causes of hospitalization in children ≤5 years old. Rapid diagnostics of viral pathogens is essential to avoid unnecessary antibiotic treatment, thereby slowing down antibiotic-resistance. We evaluated the diagnostic performance of the Luminex xTAG Respiratory Viral Panel FAST v2 against viral specific PCR as reference assays for ARI in Vietnam.
View Article and Find Full Text PDFA novel cyclovirus, CyCV-VN, was recently identified in cerebrospinal fluid (CSF) from patients with central nervous system (CNS) infections in central and southern Vietnam. To explore the geographic distribution of this novel virus, more than 600 CSF specimens from patients with suspected CNS infections in northern Vietnam, Cambodia, Nepal and The Netherlands were screened for the presence of CyCV-VN but all were negative. Sequence comparison and phylogenetic analysis between CyCV-VN and another novel cyclovirus recently identified in CSF from Malawian patients indicated that these represent distinct cycloviral species, albeit phylogenetically closely related.
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