Nail changes in pemphigus vulgaris.

Background: The frequency and types of nail changes in pemphigus vulgaris (PV) are unclear. Aim To determine the frequency and types of nail changes, and their correlation with the number of skin and periungual bullae.

Methods: Seventy-nine patients with PV, including 59 new patients and 20 patients in relapse, were entered into the study.

Abortive aphthous-like oral lesions: an underreported initial presentation of pemphigus vulgaris.

Background: Pemphigus vulgaris (PV) usually presents as non-healing, painful oral erosions, but transient or aphtha-like lesions are not exceptional at the very beginning of the disease leading to the common misdiagnosis of recurrent aphthous stomatitis (RAS). We designed this cross-sectional, questionnaire-based study to evaluate this underreported yet important presentation of PV.

Material And Methods: One hundred and eighty-five consecutive PV patients were interviewed and a questionnaire, comprising items related to the natural history of oral lesions, was filled in for each.

A study on plucked hair as a substrate for direct immunofluorescence in pemphigus vulgaris.

Background: It has recently been demonstrated in a study on 15 patients that plucked hair can be used as a substrate for direct immunofluorescence (DIF) in pemphigus.

Objective: Our aim was to assess the sensitivity of DIF on plucked hairs in pemphigus vulgaris (PV) patients with positive DIF of oral mucosa.

Methods: One hundred and ten new PV patients were enrolled in the study.

Outcome of pemphigus vulgaris.

Background: Pemphigus vulgaris can be divided into mucosal, mucocutaneous and cutaneous subtypes. A higher mortality rate has been shown with mucocutaneous involvement.

Objectives: The aim of this retrospective study was to analyse the association of clinical subtypes of pemphigus vulgaris with remission rates.

Cervicovaginal involvement in pemphigus vulgaris: a clinical study of 77 cases.

Background: Pemphigus vulgaris (PV) is an autoimmune blistering disease which is known to involve the female genital tract, but the frequency at which this occurs is unknown. There are few reports in the literature of the cytological appearance of PV on cervicovaginal smears.

Objectives: To evaluate involvement of the female genital tract and the appearance of cervicovaginal Papanicolaou (Pap) smears in PV.

Pemphigus vulgaris in Iran: a clinical study of 140 cases.

Background: Pemphigus vulgaris (PV) is a rare autoimmune blistering disease of the skin and mucous membranes. It varies in its clinical profile and epidemiologic characteristics in different parts of the world.

Objective: To determine the clinical features of PV in Iran in a prospective manner.

Desmoglein 1 and 3 enzyme-linked immunosorbent assay in Iranian patients with pemphigus vulgaris: correlation with phenotype, severity, and disease activity.

Background: Pemphigus vulgaris (PV) is a chronic autoimmune blistering disorder of the skin and mucosa characterized by the presence of autoantibodies against desmoglein3 (Dsg3). Some patients also have antibodies against desmoglein1 (Dsg1). The aims of this study were to evaluate the diagnostic value of Dsg enzyme-linked immunosorbent assay (ELISA) in Iranian PV patients, to assess its correlation with the clinical phenotype and severity of disease and to investigate the changes of these antibodies after treatment.

Isotretinoin in acne agminata.

Acne agminata is an asymptomatic papulopustular eruption. This condition typically occurs in young adults. The eruption generally runs a self-limited course, but disfiguring scars can occur.

Mucocutaneous findings in 100 children with Down syndrome.

Down syndrome is the most common chromosomal abnormality affecting numerous organs, including the skin. Our aim was to study mucocutaneous findings in this syndrome. To do so, 100 children with Down syndrome attending Schools for Children with Special Educational Needs and centers affiliated to the Welfare and Rehabilitation Organization in two provinces of Iran were thoroughly examined for skin and mucosal lesions.

Pemphigus and associated environmental factors: a case-control study.

Background: Recent reports have revealed the relatively high incidence of pemphigus in Iran. Occupational exposure and personal habits have been suggested to play a role in the aetiopathogenesis of this life-threatening disease.

Aim: In order to analyse the association of environmental factors with pemphigus, we conducted a case-control study to evaluate the possible role of smoking, pesticide exposure and hormonal factors in Iran.

Dermopathy and retinopathy in diabetes: is there an association?

Background/aims: Diabetic dermopathy is the most common cutaneous marker of diabetes mellitus presenting as single or multiple well-demarcated brown atrophic macules, predominantly on the shins. Although diabetic dermopathy and diabetic retinopathy are both considered by some authors as manifestations of diabetic microangiopathy, only a few studies are published about their possible association. Our purpose was to investigate the association of diabetic dermopathy and diabetic retinopathy.

The association of pyoderma faciale and erythema nodosum.

Pyoderma facial (PF) is a sudden severe eruption of pustules and cystic swellings which may be interconnected by sinuses. It affects mainly adult women. We report the case of a 21-year-old woman presenting with sudden onset of coalescing nodules and abscesses on the face, with mild systemic disturbance.

Cryotherapy in the treatment of pyogenic granuloma.

Background: Pyogenic granuloma is a benign, acquired, proliferative vascular lesion of the skin and mucous membranes. Many different treatments have been used for pyogenic granuloma with variable success rates.

Objective: To evaluate the efficacy of cryotherapy in the treatment of pyogenic granuloma.

The course of melanoma-associated vitiligo: report of a case.

The appearance of vitiligo-like lesions in patients with malignant melanoma is a well-known yet uncommon phenomenon. This finding is especially reported in patients undergoing immunotherapy with or without chemotherapy for malignant melanoma and is generally believed to be associated with a better prognosis. We report a case of preexisting vitiligo in a 48-year-old man, aggravated after chemo-immunotherapy of pulmonary metastatic melanoma with interferon-alpha, vinblastine and dacarbazine.

Prurigo pigmentosa: an underdiagnosed disease in patients of Iranian descent?

Background: Prurigo pigmentosa (PP) is a rare inflammatory disease of the skin typified by recurrent, pruritic erythematous macules and papules that resolve leaving behind netlike pigmentation.

Objective: PP is diagnosed most commonly in Japanese women. Preponderance of the disease in other ethnic populations has yet to be identified.

Koebner phenomenon in xanthelasma after treatment with trichloroacetic acid.

A 47-year-old woman presented with a history of yellow plaques on her eyelids. These lesions had been diagnosed clinically as xanthelasma and treated five times with topical applications of trichloroacetic acid (TCA) 33 percent. Despite flattening of the original lesions, the patient noticed extension of the lesions on the site of treatment following each session.

Anti-thyroid peroxidase antibody and vitiligo: a controlled study.

Background: Vitiligo is an acquired depigmenting disorder due to destruction of melanocytes. Although many theories have been suggested for its pathogenesis, the role of autoimmunity is the most popular one. The association of vitiligo with autoimmune thyroid diseases and the increased prevalence of autoantibodies including thyroid autoantibodies in vitiligo favor this role.

Pruritus in hemodialysis patients.

Background: Pruritus is one of the most bothersome symptoms in patients on maintenance hemodialysis (HD), however little progress is seen in our understanding of its pathogenesis. The aim of this study was to evaluate the frequency of pruritus in HD patients in Tehran, Iran, and to correlate its presence and intensity with relevant clinical and laboratory parameters.

Methods: One hundred sixty-seven patients on maintenance HD at three out-patient HD units were enrolled in the study.

Pemphigus: analysis of 1209 cases.

Background: Pemphigus is a rare and chronic life-threatening disease. The clinical picture varies in reports from different regions of the world.

Objective: To define the clinical forms of pemphigus in a large cohort of patients.

Tongue lesions in psoriasis: a controlled study.

Background: Our objective was to study tongue lesions and their significance in psoriatic patients.

Methods: The oral mucosa was examined in 200 psoriatic patients presenting to Razi Hospital in Tehran, Iran, and 200 matched controls.

Results: Fissured tongue (FT) and benign migratory glossitis (BMG) were the two most frequent findings.