Publications by authors named "Dane Koops"
Life Sci Alliance
April 2024
Article Synopsis
- Hermansky-Pudlak syndrome type 2 (HPS2) is a rare genetic disorder caused by mutations that lead to protein mis-sorting within cells, resulting in severe neutropenia.
- Using iPSCs from an HPS2 patient, researchers found that while granulocyte development was impaired, the neutrophils produced displayed characteristics similar to healthy neutrophils.
- The study revealed that despite normal viability, neutrophil yield was reduced due to macrophages phagocytosing them, indicating that both developmental delays and macrophage activity contribute to the limited neutrophil output in HPS2.
