The transforming growth factor β (TGFβ) superfamily is a master regulator of development, adult homeostasis, and wound repair. Dysregulated TGFβ signaling can lead to cancer, fibrosis, and musculoskeletal malformations. We previously demonstrated that TGFβ receptor 2 () signaling regulates odontoblast differentiation, dentin mineralization, root elongation, and sensory innervation during tooth development.
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