A wavelet subband based LSTM model for 12-lead ECG synthesis from reduced lead set.

Synthesis of a 12-lead electrocardiogram from a reduced lead set has previously been extensively studied in order to meet patient comfort, minimise complexity, and enable telemonitoring. Traditional methods relied solely on the inter-lead correlation between the standard twelve leads for learning the models. The 12-lead ECG possesses not only inter-lead correlation but also intra-lead correlation.

Development and evaluation of a chicken embryo fibroblast cell culture based live attenuated Indian strain duck plague vaccine.

Duck plague (DP) is an acute, contagious and fatal disease, caused by duck enteritis virus (DEV), with worldwide distribution causing several outbreaks and posing severe economic losses. The present study was carried out with a goal of development of a live attenuated cell culture based DP vaccine using an Indian strain of DEV and evaluation of its safety, efficacy along with complete genome analysis. The live attenuated DP vaccine (DPvac/IVRI-19) was developed by serial propagation of a virulent isolate of DEV (DEV/India/IVRI-2016) in the chicken embryo fibroblast (CEF) primary cell culture.

Exploring Public Perception Toward Travel and COVID-19 Preventive Measures: Insights From the Early Stages of Lockdown in India.

The paper reports evidence related to peoples' perceptions and attitude during the early stages of COVID-19 related lockdown in India in four major aspects: strategies and preventive measures, long-distance travel, essential services, and post-lockdown travel. A five-stage survey instrument was designed and circulated through various online modes to make it convenient to the respondents and also to achieve a greater geographical coverage within a short period of time. The survey responses were analyzed using statistical tools and the results are translated into potential policy recommendations which may be useful to implement effective interventions during future pandemics of similar nature.

Immunogenicity and protective efficacy of an inactivated Newcastle disease virus vaccine encapsulated in poly-(lactic-co-glycolic acid) nanoparticles.

An immunization experiment was conducted in specific pathogen-free chickens with the inactivated Newcastle disease virus (NDV) vaccine encapsulated in the poly-(lactic-co-glycolic) acid (PLGA) nanoparticles (NP) to evaluate its immunogenicity and protective efficacy. The NDV vaccine was prepared by inactivating one virulent Indian strain of NDV belonging to Genotype VII by using beta-propiolactone. PLGA nanoparticles encapsulating inactivated NDV were prepared by the solvent evaporation method.

Laminectomy with Rib Shears: A Technical Note.

Introduction: Laminectomy/laminoplasty either free or vascularized pedicle flap is currently performed with a variety of expensive instruments. Use of Tudor Edwards rib shears to perform above procedure is described.

Materials And Methods: Tudor Edwards rib shear was used to cut lamina in 18 cases for a variety of spinal lesions.

Is gender-based violence a confluence of culture? Empirical evidence from social media.

Gender-based violence (GBV) has been plaguing our society for long back. The severity of GBV has spurred research around understanding the causes and factors leading to GBV. Understanding factors and causes leading to GBV is helpful in planning and executing efficient policies to curb GBV.

Atrial Fibrillation Burden Estimation Using Multi-Task Deep Convolutional Neural Network.

Atrial fibrillation (AF) burden is defined as the percentage of time the patient is in AF rhythm during a certain monitoring period. The accurate AF burden estimation from the long-term electrocardiogram (ECG) recordings provides improved prognostic value compared to the traditional binary AF diagnosis (present or absent) using the snapshot ECG. However, the presence of frequent ectopic beats and different noise levels pose a challenge for precise AF burden estimation.

Evaluation of a Lipopolysaccharide and Resiquimod Combination as an Adjuvant with Inactivated Newcastle Disease Virus Vaccine in Chickens.

Various toll-like receptor (TLR) agonists have shown potential as adjuvants with different vaccines in both human and livestock species, including chickens. Our previous studies on combination of lipopolysaccharide (LPS; TLR4 agonist) and resiquimod (R-848; TLR7 agonist) showed the synergistic up-regulation of pro-inflammatory Th1 and Th2 cytokines in chicken peripheral blood mononuclear cells (PMBCs). Hence, the present study aimed to explore the combined adjuvant effect of LPS and R-848 with inactivated Newcastle disease virus (NDV) vaccine in chickens.

Complete Genome Sequence of a Virulent Duck Enteritis Virus (DEV/India/IVRI-2016) Isolated from Southern India.

Molecular characterization of Indian isolates of duck enteritis virus (DEV) so far has been limited to a few selected genomic regions. Here, we report the complete genome sequence of an isolate, DEV/India/IVRI-2016, from southern India that is 158,091 bp in length.

Acute StrokeTreatment in Children: Are Adult Guidelines Applicable?

Purpose Of This Review: This article provides an overview into acute treatments in stroke which are widely studied and available for adults and their applicability in the pediatric population.

Recent Findings: Arterial ischemic stroke is an important cause of morbidity and mortality in the pediatric population. Neurological deficits and etiologies are age-dependent and more challenging to diagnose than in the adult population.

Expression profiles of toll like receptors, MHC and cytokine genes along with viral load in organs of ducklings infected with an Indian isolate of duck enteritis virus.

A comprehensive study on the pathogenicity and host immune response was conducted in White Pekin ducklings after experimental infection with an Indian isolate of duck enteritis virus (DEV). The virus was found to be highly pathogenic and pantropic, which rapidly multiplied in various organs, mainly in the spleen and liver showing higher viral load with severe pathological lesions and caused 100% mortality. Expression profiles of immune gene transcripts in tissues (liver, spleen, brain) revealed upregulation of proinflammatory cytokines IFN-α, IFN- β, IL-1β, IL-6 and also iNOS with stimulation of TLRs (TLR-2, 3, 21).

Angiography suite cone-beam CT perfusion for selection of thrombectomy patients: A pilot study.

Background And Purpose: The availability of cone-beam CT perfusion (CBCTP) in angiography suites may improve large-vessel occlusion (LVO) triage and reduce reperfusion times for patients presenting during extended time window. We aim to evaluate the perfusion maps correlation and agreement between multidetector CT perfusion (MDCTP) and CBCTP when obtained sequentially in patients undergoing endovascular therapy.

Methods: This is a prospective, pilot, single-arm interventional cohort study of consecutive patients with anterior circulation LVO.

Seizure Types Classification by Generating Input Images With in-Depth Features From Decomposed EEG Signals for Deep Learning Pipeline.

Electroencephalogram (EEG) based seizure types classification has not been addressed well, compared to seizure detection, which is very important for the diagnosis and prognosis of epileptic patients. The minuscule changes reflected in EEG signals among different seizure types make such tasks more challenging. Therefore, in this work, underlying features in EEG have been explored by decomposing signals into multiple subcomponents which have been further used to generate 2D input images for deep learning (DL) pipeline.

Prophylactic and therapeutic insights into trained immunity: A renewed concept of innate immune memory.

Trained immunity is a renewed concept of innate immune memory that facilitates the innate immune system to have the capacity to remember and train cells via metabolic and transcriptional events to enable them to provide nonspecific defense against the subsequent encounters with a range of pathogens and acquire a quicker and more robust immune response, but different from the adaptive immune memory. Reversing the epigenetic changes or targeting the immunological pathways may be considered potential therapeutic approaches to counteract the hyper-responsive or hypo-responsive state of trained immunity. The efficient regulation of immune homeostasis and promotion or inhibition of immune responses is required for a balanced response.

Multi-Scale Convolutional Neural Network Ensemble for Multi-Class Arrhythmia Classification.

The automated analysis of electrocardiogram (ECG) signals plays a crucial role in the early diagnosis and management of cardiac arrhythmias. The diverse etiology of arrhythmia and the subtle variations in the pathological ECG characteristics pose challenges in designing reliable automated methods. Existing methods mostly use single deep convolutional neural networks (DCNN) based approaches for arrhythmia classification.

Seizure Type Classification Using EEG Based on Gramian Angular Field Transformation and Deep Learning.

classification of seizure types plays a crucial role in diagnosis and prognosis of epileptic patients which has not been addressed properly, while most of the works are surrounded by seizure detection only. However, in recent times, few works have been attempted on the classification of seizure types using deep learning (DL). In this work, a novel approach based on DL has been proposed to classify four types of seizures - complex partial seizure, generalized non-specific seizure, simple partial seizure, tonic-clonic seizure, and seizure-free.

Classification of Epileptic Seizure From EEG Signal Based on Hilbert Vibration Decomposition and Deep Learning.

A convolution neural network (CNN) architecture has been designed to classify epileptic seizures based on two-dimensional (2D) images constructed from decomposed mono-components of electroencephalogram (EEG) signals. For the decomposition of EEG, Hilbert vibration decomposition (HVD) has been employed. In this work, four brain rhythms - delta, theta, alpha, and beta have been utilized to obtain the mono-components.

Cerebral Venous Sinus Thrombosis Associated With Coronavirus Disease 2019: Case Report and Review of the Literature.

Introduction: Coronavirus disease 2019 (COVID-19) is associated with significant risk of acute thrombosis. We present a case report of a patient with cerebral venous sinus thrombosis (CVST) associated with COVID-19 and performed a literature review of CVST associated with COVID-19 cases.

Case Report: A 38-year-old woman was admitted with severe headache and acute altered mental status a week after confirmed diagnosis of COVID-19.

A diagnostic information based framework for super-resolution and quality assessment of retinal OCT images.

High-resolution (HR) retinal optical coherence tomography (OCT) images are preferred by the ophthalmologists to diagnose retinal diseases. These images can be obtained by dense scanning of the target retinal region during acquisition. However, a dense scanning increases the image acquisition time and introduces motion artefacts, which corrupt diagnostic information.

Analyzing the vocal tract characteristics for out-of-breath speech.

In this work, vocal tract characteristic changes under the out-of-breath condition are explored. Speaking under the influence of physical exercise is called out-of-breath speech. The change in breathing pattern results in perceptual changes in the produced sound.

Optimal Woven EndoBridge (WEB) Device Size Selection Using Automated Volumetric Software.

Introduction: Selecting the appropriate Woven EndoBridge (WEB) device sizing for the treatment of wide-neck bifurcation aneurysms (WNBAs) remains challenging. The aim of this study was to evaluate different volumetric-based imaging methodologies to predict an accurate WEB device size selection to result in a successful implantation.

Methods: All consecutive patients treated with WEB devices for intracranial aneurysms from January 2019 to June 2020 were included.

Safety and Feasibility of Symptomatic Carotid Artery Stent-Assisted Revascularization within 48 Hours after Symptoms Onset.

Objective: We aimed to evaluate the safety and feasibility of carotid artery stenting (CAS) performed in the hyperacute period.

Methods: We analyzed a retrospective database of CAS patients from our center. We included patients with symptomatic isolated ipsilateral extracranial carotid stenosis and acute tandem occlusions who underwent CAS.

Absent hyperdense middle cerebral artery sign is associated with poor functional outcome after mechanical thrombectomy.

Background: The hyperdense middle cerebral artery sign on computed tomography indicates proximal middle cerebral artery occlusion. Recent reports suggest an association between the hyperdense sign and successful reperfusion. The prognostic value of the hyperdense middle cerebral artery sign in patients receiving mechanical thrombectomy has not been extensively studied.

Combined Transradial and Transfemoral Approach Using a Compliant Balloon for Emboli Protection at the Vertebral Artery During Subclavian Stenosis Stenting: 2-Dimensional Operative Video.

Endovascular intervention has become the mainstay of treatment for subclavian artery stenosis in many centers, with high technical success and low complication rates.1,2 However, potential embolization during proximal subclavian artery intervention can lead to catastrophic posterior circulation ischemic complications.3-5 Although considered a rare complication, the presence of a contralateral hypoplastic vertebral artery with persisting anterograde vertebral blood flow on the affected side is likely to increase the risk of embolization.