Publications by authors named "Dandan Wei"

Abdominal wall defects caused by trauma, congenital rupture, and intra-abdominal infection remain challenging due to the large wound area and complex complications. Herein, an assembled mesenchymal stem cell (MSCs)-laden granular hydrogel (termed assembled GSD@FPs), loaded with basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF), was developed. This hydrogel was constructed through dynamic covalent cross-linking (via borate ester bonds) among dopamine-grafted gelatin methacrylamide (GelMA-DA), phenylborate-modified hyaluronic acid (HA-PBA), and epigallocatechin-3-gallate (EGCG), serving as multifunctional bulk building blocks for cell delivery and abdominal wall repair.

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The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in millions of deaths and continues to pose serious threats to global public health. The main protease (M) of SARS-CoV-2 is crucial for viral replication and its conservation, making it an attractive drug target. Here, we employed a structure-based drug design strategy to develop and optimize novel inhibitors targeting SARS-CoV-2 M.

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Background: Bloodstream infections (BSIs) caused by have been associated with high mortality. To improve the outcomes of patients, this study explored the clinical characteristics and outcomes of patients with BSIs, as well as the phenotypic and genomic characteristics of these isolates.

Methods: A retrospective cohort study was conducted involving BSIs cases from 2020 to 2023 in a tertiary hospital.

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The present study examines the relationship between future self-continuity (FSC) and grit in college students, focusing on the mediating role of future time perspective (FTP) and its dimensions. A survey was conducted among 389 college students from universities in Beijing and Guizhou Province using relevant questionnaires. The results show the following: (1) FSC positively predicts grit (r = 0.

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This study aims to employ poly-L-lactic acid (PLLA) and poly(p-dioxanone) (PPDO), loaded with naringin (NAR) to fabricate a functionalized degradable mesh which can promote abdominal wall hernia (AWH) repair. Three meshes named PPDO, PLLA/PPDO, and PLLA/PPDO/NAR were fabricated by electrospinning. The physical and chemical properties of the meshes were evaluated from the aspects of morphology, wettability, chemical composition, mechanical properties, anddegradation.

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Ferroptosis is a unique modality of regulated cell death induced by excessive lipid peroxidation, playing a crucial role in tumor suppression and providing potential therapeutic strategy for cancer treatment. Here, we find that aldehyde dehydrogenase-ALDH3A1 tightly links to ferroptosis in squamous cell carcinomas (SCCs). Functional assays demonstrate the enzymatic activity-dependent regulation of ALDH3A1 in protecting SCC cells against ferroptosis through catalyzing aldehydes and mitigating lipid peroxidation.

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The widespread use of synthetic phenolic antioxidants (SPAs) has led to their ubiquity and may contribute to multiple adverse health outcomes by affecting hormone level disruption. This study aimed to assess the exposure levels of SPAs in the plasma of the normoglycemic rural Chinese population, investigate the association of single and mixed pollutant exposures with sex hormones, and analyze the moderating role of body mass index (BMI) in these relationships. A cross-sectional study including 763 individuals with normal blood glucose from the Henan Rural cohort was conducted.

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Climate warming is affecting the ranges and population dynamics of invasive species, including insects, which have become a global problem, causing biodiversity declines and agricultural economic losses. Anthonomus eugenii as an important invasive pest on pepper is now mainly located in the USA and Mexico. However, the global potential geographic distribution (PGD) of A.

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Background: Booklice, belonging to the genus Liposcelis (Psocodea: Liposcelididae), commonly known as psocids, infest a wide range of stored products and are implicated in the transmission of harmful microorganisms such as fungi and bacteria. The olfactory system is critical for insect feeding and reproduction. Elucidating the molecular mechanisms of the olfactory system in booklice is crucial for developing effective control strategies.

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The novel pathogen, Elizabethkingia anophelis, has gained attention due to its high mortality rates and drug resistance facilitated by its inherent metallo-β-lactamases (MBLs) genes. This study successfully identified and outlined the functions of the B3-Q MBLs variant, GOB-38, in a clinical sample of E. anophelis.

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Background And Purpose: Recent studies link pesticide exposures to cardiovascular disease risk factors. However, research on the combined effects of multiple pesticides on atherosclerotic cardiovascular disease (ASCVD) is limited, particularly in rural areas. Despite advances in toxicogenomics, the mechanisms underlying these effects remain unclear.

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Liposcelis tricolor (Psocoptera: Liposcelididae) is a significant pest affecting stored products globally. However, due to the lack of a detailed genomic reference, the mechanisms of sex determination, stress resistance, and potential control methods for this booklouse remain poorly understood. In this study, the chromosome-level genome of L.

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Unlabelled: Soil microorganisms play a crucial role in suppressing soil-borne diseases. Although the composition of microbial communities in healthy versus diseased soils is somewhat understood, the interplay between microbial interactions and disease incidence remains unclear. This study used 16S rRNA and fungal internal transcribed spacer (ITS) sequencing to investigate the bacterial and fungal community composition in three soil types: forest soil (Z), soil from healthy banana plantations (H), and soil from diseased banana plantations (D).

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Article Synopsis
  • - The study explored how exposure to polychlorinated biphenyls (PCBs) affects vitamin D levels differently in people with type 2 diabetes (T2DM) compared to those with normal glucose tolerance (NGT).
  • - Among 1,705 participants, PCB exposure was linked to increased vitamin D2 levels in the NGT group, while it correlated with decreased vitamin D3 and overall vitamin D levels in the T2DM group.
  • - The research highlighted that diminished β cell function in T2DM patients potentially worsens the negative impact of PCB exposure on vitamin D levels, emphasizing the need for targeted health protections for this population.
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Cefiderocol (FDC) is an effective antibiotic that is used to treat severe infections caused by carbapenem-resistant (CRKP). The mechanisms underlying FDC resistance and molecular epidemiology in China remain unclear. We collected 477 non-duplicate CRKP clinical isolates in central China and characterized their susceptibility to FDC, virulence genes, and sequence typing.

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Article Synopsis
  • The study investigates Carbapenem-resistant and hypervirulent Klebsiella pneumoniae (CR-hvKP) to understand its epidemiology, resistance, and virulence characteristics in different regions of China, aiming to inform prevention strategies.
  • *Out of 609 K. pneumoniae strains collected, 45 (7.4%) were identified as CR-hvKP, with a higher prevalence in Nanchang compared to Jiujiang; the dominant strain was ST11-KL64, indicating significant genetic diversity and cross-regional transmission.
  • *The findings suggest that ST11-KL64 CR-hvKP evolved from previous strains by acquiring a modified virulence plasmid, highlighting the need for enhanced surveillance and control measures to combat
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Herein we report a general rhodium-catalyzed asymmetric intermolecular dearomative cyclopropanation of indoles using trifluoromethyl N-triftosylhydrazones as carbene precursors. The reaction enables the rapid construction of diverse cyclopropane-fused indolines bearing a trifluoromethylated quaternary stereocenter with high enantioselectivity (up to 99 % ee). This mild method exhibits broad substrate scope, tolerating various functional groups, and can even be utilized for the late-stage diversification of complex bioactive molecules.

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Background: Acinetobacter baumannii (A. baumannii) has become a significant nosocomial pathogen globally over the past decade due to the increasing prevalence of antibiotic-resistant isolates. The formation of the mucoid phenotype is a crucial adaptive defense response to external pressure, but the clinical, phenotypic and genotypic characteristics and their relationship with sequence types (ST) and K locus (KL) types remain unclear.

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There is no evidence on the associations between persistent organic pollutants (POPs) and the incidence of chronic kidney disease (CKD) in the Chinese rural population. We aimed to investigate the individual and mixed effects of 22 POPs on the prevalence and incidence of CKD, and the joint effects of POPs and abnormal glucose metabolism as well as the modification effects of healthy lifestyle on these associations. A total of 2775 subjects, including 925 subjects with normal plasma glucose (NPG) and 925 subjects with prediabetes (PDM) and type 2 diabetes mellitus (T2DM), were enrolled from the Henan Rural Cohort Study.

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Presently, the non-biodegradable polypropylene (PP) patches frequently used for hernia repair can cause fibrous tissue growth and adhesions. This study created a Janus Patch with anti-adhesion and antimicrobial properties to improve hernia repair while promoting tissue repair. The biologically active 4arm-PLGA-BLPD was initially synthesized through the modification of 4arm-PLGA with lysine, followed by the fabrication of a Janus patch using a layer-by-layer electrostatic spinning technique.

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Article Synopsis
  • The study investigates the long-term and causal links between exposure to multiple pesticides and the development of type 2 diabetes mellitus (T2DM) in the rural Chinese population, while also assessing the role of physical activity (PA) in these associations.
  • Researchers analyzed data from 1,850 participants, examining the effects of 51 pesticides and using various statistical methods, including logistic regression and Mendelian randomization to establish causality.
  • The results showed that higher levels of certain pesticides significantly increased the risk of T2DM, especially in individuals with impaired fasting glucose (IFG), and low levels of physical activity further exacerbated this risk.
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As cities strive for ambitious increases in tree canopy cover and reductions in anthropogenic volatile organic compound (AVOC) emissions, accurate assessments of the impacts of biogenic VOCs (BVOCs) on air quality become more important. In this study, we aim to quantify the impact of future urban greening on ozone production. BVOC emissions in dense urban areas are often coarsely represented in regional models.

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To investigate the associations between isocarbophos and isofenphos with impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM), and to assess the mediation roles of inflammation cells. There were 2701 participants in the case-control study, including 896 patients with T2DM, 900 patients with IFG, 905 subjects with NGT. Plasma isocarbophos and isofenphos concentrations were measured using gas chromatography and triple quadrupole tandem mass spectrometry.

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Article Synopsis
  • The study aimed to assess how exposure to neonicotinoids (a type of pesticide) relates to cardiometabolic risk over three years, while also looking at the role of inflammatory markers and platelet traits as mediators.
  • A cohort of 2,315 participants was initially studied, with 1,841 completing follow-up assessments, and various statistical methods were employed to analyze the relationships between pesticide exposure and cardiometabolic indicators.
  • Results showed a positive correlation between neonicotinoid exposure and increased cardiometabolic risk, particularly for insulin resistance and triglycerides, indicating that inflammatory markers and platelet traits play significant roles in this relationship.
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