Prognostic factors and survival outcomes of immunohistochemically detection based-molecular subtypes of endometrial cancer-analysis of 576 clinical cases.

Objective: The study aimed to identify distinct molecular subtypes of endometrial cancer (EC) by immunohistochemistry and to analyze their pathological characteristics, independent prognostic factors, and patient survival outcomes for potential clinical applications.

Method: 576 patients with preoperative EC confined to the uterus were divided into three subgroups based on the immunohistochemical detection method: MMR-deficiency (MMRd), P53 wild type (P53wt) and P53 abnormal (P53abn). These subgroups were retrospectively analyzed, and their pathological characteristics, prognostic factors and survival outcomes were compared.

Cognitive Remediation in Patients With Bipolar Disorder: A Randomized Trial by Sequential tDCS and Navigated rTMS Targeting the Primary Visual Cortex.

Background: Non-invasive brain stimulation (NIBS), such as transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS), has emerged as a promising alternative in the precise treatment of clinical symptoms, such as the cognitive impairment of bipolar disorder (BD). Optimizing the neurocognitive effects by combining tDCS and rTMS to strengthen the clinical outcome is a challenging research issue.

Objective: In this randomized, controlled trial, we first combined tDCS and neuronavigated rTMS targeting the V1 region to explore the efficacy on neurocognitive function in BD patients with depressive episodes.

The protective role of gamma zone peripapillary atrophy in diabetic retinopathy: insights from deep learning and SS-OCT angiography.

Purpose: To explore the relationship between peripapillary atrophy (PPA) and diabetic retinopathy (DR), and to uncover potential mechanisms using swept-source optical coherence tomography (SS-OCT) angiography.

Methods: This cross-sectional study included 845 patients with type 2 diabetes (T2DM), who underwent detailed systemic and ophthalmic evaluations. A state-of-the-art deep learning method was employed to precisely identify the parapapillary beta and gamma zones.

Bifidobacterium animalis ssp. lactis BX-245-fermented milk alleviates tumor burden in mice with colorectal cancer.

Colorectal cancer (CRC) arises from the accumulation of abnormal mutations in colorectal cells during prolonged inflammation. This study aimed to investigate the potential of probiotic fermented milk containing the probiotic strain, Bifidobacterium animalis ssp. lactis BX-245 (BX-245), in alleviating tumor burden in CRC mice induced by azoxymethane and dextran sodium sulfate.

Programming Bifunctional Metal-Organic Frameworks to Integrate Multiple Triboelectric Nanogenerators for Green Electronics toward Effective Self-Powered Photocatalytic System.

Programming and synthesizing bifunctional materials for regulating the output of triboelectric nanogenerators (TENGs) and their photocatalytic efficiency is a promising strategy for energy harvesting to build self-powered systems. Herein, we tackle this challenge by introducing metal-organic frameworks (MOFs) as molecular catalysts and triboelectric layers for self-powered photocatalytic systems. A zeolite-like mixed-valence MOF () and a ladder-structured MOF () were obtained through structural transformation.

COSMIC-2 RFI Prediction Model Based on CNN-BiLSTM-Attention for Interference Detection and Location.

As the application of the Global Navigation Satellite System (GNSS) continues to expand, its stability and safety issues are receiving more and more attention, especially the interference problem. Interference reduces the signal reception quality of ground terminals and may even lead to the paralysis of GNSS function in severe cases. In recent years, Low Earth Orbit (LEO) satellites have been highly emphasized for their unique advantages in GNSS interference detection, and related commercial and academic activities have increased rapidly.

Green Synthesis of Silver Nanoparticles (CM-AgNPs) from the Root of for Improving the Cytotoxicity Effect in Cancer Cells with Antibacterial and Antioxidant Activities.

The unique properties of silver nanoparticles (AgNPs), such as size, surface charge, and the ability to release silver ions, contribute to DNA damage, inducing of oxidative stress, and apoptosis in cancer cells. Thus, the potential application of AgNPs in the field of biomedicine, and cancer therapy are rapidly increasing day by day. Therefore, in this study, AgNPs were synthesized by extract of , and then the synthesized CM-AgNPs were fully characterized.

High-Efficiency Gold Nanoaggregates for NIR LED-Driven Sustained Mild Photothermal Therapy Achieving Complete Tumor Eradication and Immune Enhancement.

For millennia, humans have harnessed thermal energy to treat cancer. However, delivering energy to tumor tissues in traditional hyperthermia remains a significant challenge. Nanotechnology has revolutionized this approach, enabling nanomaterials to target tumors precisely and act as internal heat sources.

Mitophagy in gynecological malignancies: roles, advances, and therapeutic potential.

Mitophagy is a process in which impaired or dysfunctional mitochondria are selectively eliminated through the autophagy mechanism to maintain mitochondrial quality control and cellular homeostasis. Based on specific target signals, several mitophagy processes have been identified. Defects in mitophagy are associated with various pathological conditions, including neurodegenerative disorders, cardiovascular diseases, metabolic diseases, and cancer.

Assembling and dietary application of a local trnL metabarcoding database for in Taohongling Nature Reserve.

The quality and completeness of the reference database have a direct impact on the accuracy of forage plant identification, thereby influencing the level of conservation and management of wildlife resources. In our research, target amplification was subjected to first-generation sequencing to assemble a local reference database using chloroplast trnL metabarcoding. We found that the primers c-h outperformed g-h as a universal DNA metabarcoding and 162 valid choloroplast trnL sequences were submitted (GenBank ID: PP081756 - PP081917), which exhibited an obvious preference for A and T nucleotides (60.

Mitochondria-targeting artesunate-rhein conjugates: Linker-modulated cell-permeability, heme-affinity and anticancer activity.

Heme, abundant in the mitochondria of cancer cells, is a key target for the anticancer activity of artemisinin (ART). Current strategies to enhance the anticancer activity of ART focus solely on its delivery to heme-enriched subcellular localizations while overlooking the decisive effects of ART-heme interactions. Here, we propose an ingenious strategy that synergizes mitochondria-targeted drug delivery and linker-mediated drug conformation modulation, thereby significantly enhancing the anticancer activity of ART.

Modulating Fe sites by La in porous MnFeO for enhanced removal of ROX: Synergy of efficient adsorption and PMS activation.

Catalytic-adsorption method is a promising strategy for degrading organoarsenic compounds and removing secondary inorganic arsenic. The method relies significantly on heterogeneous catalysts with selectively adsorption and enhanced peroxymonosulfate (PMS) activation capacity. In this study, active sites for selective adsorption and PMS activations were developed by modulating the Fe-sites in porous MnFeO through La-doping.

Development of a non-targeted metabolomics-based screening method for elucidating the metabolic characteristics and potential applications of Lacticaseibacillus paracasei.

The increasing demand for healthy foods has led to widespread interest in lactic acid bacteria due to their potential health benefits. We propose the hypothesis that Lacticaseibacillus paracasei (L. paracasei) can produce beneficial metabolites under specific conditions, which offers potential applications in functional foods.

Flexible Triboelectric Nanogenerators Based on Cadmium Metal-Organic Framework/Eethyl Cellulose Composites as Energy Harvesters for Selective Photoinduced Bromination Reaction.

The fabrication of self-driven systems with flexibility and tunable output for organic photoinduction is highly desirable but challenging. In this study, a 3D cadmium metal-organic framework (Cd-MOF) is synthesized and used as a filler for ethyl cellulose (EC) to create mechanically durable and flexible Cd-MOF@EC composite films. Due to its well-established platform with periodically precise structure nature, the outputs of Cd-MOF-based TENG are much higher than those of ligand-based TENGs.

Frontotemporal structure preservation underlies the protective effect of lifetime intellectual cognitive reserve on cognition in the elderly.

Background: Cognitive decline with age has heterogeneous, which might be related to the accumulation of protective factors called cognitive reserve, especially intellectual engagement factors over the life course. However, how lifetime intellectual cognitive reserve (LICR) protects cognitive function in the elderly remains unclear. We aimed to examine the relationship between LICR and cognition and the mild cognitive impairment (MCI) risk, as well as the neural mechanism of LICR on cognition.

Renal remodeling by CXCL10-CXCR3 axis-recruited mesenchymal stem cells and subsequent IL4I1 secretion in lupus nephritis.

Human umbilical cord mesenchymal stem cells (hUC-MSCs) have shown potential as a therapeutic option for lupus nephritis (LN), particularly in patients refractory to conventional treatments. Despite extensive translational research on MSCs, the precise mechanisms by which MSCs migrate to the kidney and restore renal function remain incompletely understood. Here, we aim to clarify the spatiotemporal characteristics of hUC-MSC migration into LN kidneys and their interactions with host cells in microenvironment.

CoFe Hydroxide Nanospheres for Enhanced Alkaline Water Splitting and Seawater Oxidation:Anion Doping Effects of Fluorine and Carbonate.

Green hydrogen production can be achieved through electrolysis of fresh water or the use of renewable energy to electrolyze seawater. However, due to the low activity and poor stability of oxygen evolution reaction catalysts, direct electrolysis of alkaline seawater faces significant challenges. Herein, The catalyst F-CoFe(OH)-CO/NF with three-dimensional nanosphere structure was prepared, The introduction of CO into the intermediate layer of CoFe hydroxide improves the corrosion resistance of alkaline electrolyte and the doping of F is to design three-dimensional layered nanostructures, increase the active site, and accelerate the diffusion of the electrolyte.

Folic Acid Attenuates N-Methyl-N'-Nitro-N-NitrosoguanidineInduced Gastric Mucosal Injury in Rats.

Background/aims: N-Methyl-N'-nitroso-N-nitrosoguanidine (MNNG) is suspected to increase the risk of developing stomach cancer. Folic acid (FA) is familiar with decreasing inflammation. We expected that FA would protect against MNNG-induced gastric mucosal injury.