Neferine inhibits the progression of diabetic nephropathy by modulating the miR-17-5p/nuclear factor E2-related factor 2 axis.

Objective: To investigate the effect of Neferine (Nef) on diabetic nephropathy (DN) and to explore the mechanism of Nef in DN based on miRNA regulation theory.

Methods: A DN mouse model was constructed and treated with Nef. Serum creatinine (Crea), blood urea (UREA) and urinary albumin were measured in mice by kits, and renal histopathological changes and fibrosis were observed by hematoxylin-eosin staining and Masson staining.

Cystoid Macular Edema 18 Years after Anterior Chamber Phakic Intraocular Lens Implantation.

We report a case of a 54-year-old female patient who underwent PAC-IOL implantation 18 years prior to presentation. The patient had a best corrected visual acuity (BCVA) 20/20 in the right eye (OD) postoperatively with normal eye exam on routine follow-up since then. The patient presented for acute onset decreased visual acuity in the right eye.

MiR-320d Inhibits Progression of EGFR-Positive Colorectal Cancer by Targeting TUSC3.

The mechanism of miR-320d in EGFR-positive colorectal cancer (CRC) has not been fully elucidated. The aim of the present study was to explore the molecular mechanism of miR-320d in CRC. The miRNA microarray analysis was conducted to identify differential expressed miRNAs.

[Chemical profiling and tissue distribution study of Jingyin Granules in rats using UHPLC-Q-Exactive Orbitrap HR-MS].

In this study, the chemical profiling of Jingyin Granules and the tissue distribution of nine major constituents in this Chinese medicine were performed after oral administration of Jingyin Granules to rats, by using UHPLC-Q-Exactive Orbitrap HR-MS. An Acquity UPLC BEH C_(18) chromatographic column(2.1 mm×100 mm, 1.

Long noncoding RNA MIR31HG is activated by SP1 and promotes cell migration and invasion by sponging miR-214 in NSCLC.

Long non-coding RNAs(lncRNAs) have been reported to play pivotal roles in various cancers. Recently, MIR31HG was proposed to be involved in tumor progression. However, its role in non small cell lung cancer(NSCLC) remains elusive.

Effects of femtosecond and excimer lasers on implanted KAMRA corneal inlay in animal models.

Purpose: To evaluate the effect of femtosecond laser and excimer laser on an intracorneal inlay (KAMRA) implanted in animal models.

Methods: Femtosecond laser was used to create corneal intrastromal pockets at 250μm depth in five porcine eyes. Four intact KAMRA inlays, examined by slit-lamp biomicroscopy and light microscopy, were implanted in the pocket of four eyes.

A Newly-Discovered Mutation in the RFX6 Gene of the Rare Mitchell-Riley Syndrome.

Mitchell-Riley syndrome is a genetic disorder characterized by neonatal diabetes, pancreatic hypoplasia, intestinal atresia and/or malrotation, biliary atresia, and gallbladder aplasia or hypoplasia. It was considered a variant of the Martinez-Frias syndrome with similar phenotypic characteristics, except for neonatal diabetes and tracheoesophageal fistula. However, the genetic mutation in (regulatory factor X on chromosome 6) RFX6 was only detected in babies who had diabetes, making it different from the previously known mutations for the disease.

[Secondary productivity of macrobenthos in intertidal flat of Luoyuan Bay, Fujian Province of East China].

Based on the survey data of macrobenthos in the intertidal flat of Luoyuan Bay in 2009, and by using Brey' s empirical formula, this paper estimated the macrobenthos secondary productivity, production/biomass (P/B) ratio, and their spatiotemporal distribution patterns in the flat. The annual secondary productivity and P/B ratio of the macrobenthos in the flat were estimated as 18.58 g AFDM (ash free dry mass) x m(-2) x a(-1) and 0.

Good interobserver and intraobserver agreement in the evaluation of the new ILAE classification of focal cortical dysplasias.

Purpose: An International League Against Epilepsy (ILAE) consensus classification system for focal cortical dysplasias (FCDs) has been published in 2011 specifying clinicopathologic FCD variants. The aim of the present work was to microscopically assess interobserver agreement and intraobserver reproducibility for FCD categories among an international group of neuropathologists with different levels of experience and access to epilepsy surgery tissue.

Methods: Surgical FCD specimens covering a broad histopathology spectrum were retrieved from 22 patients with epilepsy.

The value of spatiotemporal image correlation technique in the diagnosis of fetal ventricular septal defect.

Objective: To investigate the value of spatiotemporal image correlation (STIC) technique in the ventricular septal defect diagnosis.

Methods: A total of 1,163 fetuses were enrolled in this study, diagnosed by fetal echocardiography and analyzed by STIC technique. We obtained effective STIC volumes from the fetus according to the Goncalves' report, and judged fetal cardiac structure from STIC volume information again with a double-blind method.