Publications by authors named "Dandan Pi"
Article Synopsis
- Pediatric sepsis is a serious condition marked by an abnormal immune response to infection, and this study examines the role of the renin-angiotensin system (RAS) in it.
- Serum samples from patients with sepsis, critically ill controls, and healthy individuals were analyzed to assess levels of renin and angiotensin (1-7) on the day of admission to the pediatric intensive care unit.
- Findings indicated that higher renin levels and lower angiotensin (1-7) levels in sepsis patients are associated with worse outcomes, suggesting these markers could be useful for predicting the severity and survival in pediatric sepsis.
Septic shock is a life-threatening disease worldwide often associated with thrombocytopenia. Platelets play a crucial role in bridging the gap between immunity, coagulation, and endothelial cell activation, potentially influencing the course of the disease. However, there are few studies specifically evaluating the impact of thrombocytopenia on the prognosis of pediatric patients.
View Article and Find Full Text PDFUnlabelled: The role of inflammatory cytokines in children with moderate to severe TBI (m-sTBI) is still incompletely understood. We aimed to investigate the associations between early plasma expression profiles of inflammatory cytokines and clinical outcomes in children with m-sTBI. We prospectively recruited children admitted to the intensive care unit (ICU) of a tertiary pediatric hospital due to m-sTBI from November 2022 to May 2023.
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- A study investigated the relationship between lung microbiome and pulmonary diseases using a mouse model of acute lung injury (ALI), focusing on different specimen types for evaluation.
- Researchers found that bronchoalveolar lavage fluid (BALF) and intact lung tissue (Lung(i)) were suitable for assessing the lung microbiome, while perfused lung tissue (Lung(p)) showed greater variability and was less reliable.
- Key findings indicated that specific bacterial phyla, particularly Actinobacteria and Firmicutes, could be important biomarkers for the severity of lung injury, suggesting a link between the gut and lung health.
Background: Sepsis is a severe condition characterized by acute organ dysfunction resulting from an imbalanced host immune response to infections. Apolipoprotein H (APOH) is a critical plasma protein that plays a crucial role in regulating various biological processes. However, the precise role of APOH in the immunopathology of paediatric sepsis remains unclear.
View Article and Find Full Text PDFTo perform a mental health evaluation and an early psychological intervention for healthcare workers (HCWs) during the coronavirus disease 2019 (COVID-19) epidemic, an online survey was conducted among 3055 HCWs in the paediatric intensive care units (PICUs) of 62 hospitals in China on March 26, 2020, by the Neurology and Sedation Professional Group, Emergency Department, Paediatrics Branch, Chinese Medical Association. The questionnaire was divided into three parts, including general information, the Impact of Event Scale-Revised (IES-R), and the Depression Anxiety Stress Scale-21 (DASS-21). The results show that a total of 970 HCWs (45.
View Article and Find Full Text PDFBackground: Talaromyces marneffei (T. marneffei) is a thermally dimorphic fungus causing systemic mycosis. Due to the atypical symptoms and diverse imaging findings, T.
View Article and Find Full Text PDFis a pathogen causing an increasing number of pediatric infections. The objective of this study was to investigate the clinical characteristics of infections in children. As a retrospective analysis, clinical features and drug susceptibility data of the five cases were analyzed and related literature was reviewed.
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