THE STATE OF THE CYSTATHIONINE GAMMA-LYASE / H2S SYSTEM IN THE LIVER AND SKELETAL MUSCLES OF RATS WITH HYPERCHOLESTEROLEMIA UNDER SIMVASTATIN ADMINISTRATION.

In studies on 94 male Wistar rats changes in the hydrogen sulfide content (H2S) and cystathionine γ-lyase (CSE) in the liver and skeletal muscles in hypercholesterolemia under simvastatin treatment were assessed, as well as the effect of propargylglycine (PAG) on hepato- and myotoxicity of simvastatin. It was determined, that simvastatin inhibited the CSE-mediated synthesis of H2S in the main target organs. This negatively affected their biochemical and functional status.

[Mechanisms of support prooxidant-antioxidant balance in the liver tissues of geese in hypo- and hyperoxia].

The mechanisms of support of the prooxidant-antioxidant balance in the liver tissues of geese in hypo- and hyperoxia during the transition from embryonic to postnatal development. It is proved that the formation of adaptive response to these conditions by running the neuro-humoral mechanisms that are, first, to stimulate the synthesis of antioxidants of protein nature, and secondly, to reduce the unsaturation of fatty acids in the lipids of the liver, which greatly increases their resistance to the active forms of oxygenation and thirdly, to increase the efficiency of the antioxidant defense system by improving the consistency of its components performance.

[Formation of antioxidant defence system of geese in embryogenesis and early postnatal ontogenesis].

The features of antioxidant protection of tissues of a liver and blood of the gooses in embriogenesis and early postnatal ontogenesis are found out. Maximal contents TBA active products both in a liver, and in a blood are observed in 28 diurnal embriones. Is shown, that in a liver the activity of basic antioxidant enzymes (superoxide dismutases, catalase and glutathione peroxidase) in a liver is developed already at early stages embriogenesis and is considerably enlarged in the end embriogenesis.

[Ontogenic characteristics of lipid peroxidation and antioxidant system enzymes in the brain of geese].

Peculiarities of antioxidant homeostasis of geese brain tissue during embryogenesis and early postnatal period have been studied. It has been shown that the cerebrum and hindbrain tissues are characterized by a higher level of lipid peroxidation compared to liver. Main antioxidative enzymes' activity (superoxide dismutase, catalase, glutathione peroxidase) in the brain already reaches its maximum in the middle period of embryogenesis.

[Ontogenic characteristics of changes in fatty acid composition of the liver lipids as a main substrate for peroxidation in geese].

Dynamics of fatty acid composition of geese liver lipids in embryogenesis and early postnatal period has been investigated. High nonsaturation of these tissues lipids is shown during all the period of researches. It is established, that in the second half of embryogenesis and in the beginning of postnatal period (first two weeks) the increase of oleic acid contents is observed with simultaneous decrease of the contents of the polynonsaturated fatty acids (PUFA) showing properties of endogenous bioregulators (arachidonic acid (AA), docosahexaenoic acid [figure: see text] (DHA).

[Features of the antioxidant homeostasis of goose liver in early postnatal ontogenesis].

The research of features antioxidant status in early postnatal ontogenesis at the geese with an early target level pereoxidation is conducted. The very high target level of lipid pereoxidation (FLOOR) compared with the hens is shown, that at gees in norm. Are established (installed) laws of changes a FLOOR in liver of the geese on the first month of life.

[Diagnostic and surgical laparoscopy in polycystic ovary syndrome].

A total of 202 patients with polycystic ovaries were involved in examination. The study has distinguished the laparoscopic signs of polycystic ovaries: smooth glossy tightly stretched surface of the ovaries with a characteristic vascular pattern or loops; the presence of subcapsular cysts. Ovarian section shows small cysts with transparent or yellowish contents.

[Effectiveness of infertility therapy in patients with hyperandrogenism].

170 patients of reproductive age with hyperandrogenemia and infertility were examined. 101 (59.4%) patients became pregnant after the complete therapy of infertility.

[The role of endoscopic methods in the diagnosis of endocrine infertility in women with persistent anovulation].

The incidence of stubborn anovulation in patients ineffectively treated with hormones has made up. 22.7%.