Rational Design and Identification of Novel Piperine Derivatives as Multichitinase Inhibitors.

Asian corn borer () is one of the most destructive pests in agriculture. Three chitinases ChtI, ChtII, and Chi-h are regarded as potential targets for discovering novel agrochemicals to control . In this study, piperine ( = 43.

Design, synthesis, biologically evaluation and molecular docking of C-glycosidic oximino carbamates as novel OfHex1 inhibitors.

The inhibition of function-specific β-N-acetyl-D-hexosaminidases, such as OfHex1 from the Asian corn borer (Ostrinia furnacalis), is a promising strategy for the development of green pesticides. Among reported OfHex1 inhibitors, glycosyl inhibitors show especially high inhibitory activity. In this study, a series of novel C-glycosidic oximino carbamate derivatives were designed using the OfHex1 crystal structure and synthesized.