Publications by authors named "Danai Liaropoulou"
Article Synopsis
- The downregulation of Amyloid Precursor Protein (APP) in SH-SY5Y cells using short hairpin RNA (shRNA) affects the expression of various ion channels and signaling proteins critical for synaptic function.
- Increased levels of GluR2 and GluR4 subunits of AMPAR, along with upregulated endoplasmic reticulum proteins like IPR and RyR, were observed in APP-knockdown cells.
- APP's role appears to interconnect calcium signaling pathways, with reduced calcium mobilization responses indicating its crucial function in maintaining synaptic and cellular signaling integrity.
The two crucial cellular insults that take place during cerebral ischemia are the loss of oxygen and loss of glucose, which can both activate a cascade of events leading to neuronal death. In addition, the toxic overactivation of neuronal excitatory receptors, leading to Ca overload, may contribute to ischemic neuronal injury. Brain ischemia can be simulated in vitro by oxygen/glucose deprivation, which can be reversible by the re-establishment of physiological conditions.
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