A new device for creating and positioning an autogenous cartilage framework during microtia reconstruction.

Objective: This paper describes the fabrication and use of a three-dimensional appliance, known as the microtia surgical positioner, to more accurately position and better sculpt the autogenous rib cartilage graft during microtia reconstruction.

Study Design: The authors introduce a new device design and surgical application.

Methods: An impression and plaster cast were made from the patient's auricular defect.

Primary hyperparathyroidism in an adult female olive baboon (Papio anubis).

During an annual physical examination, a middle-aged adult female olive baboon (Papio anubis) in the time-mated breeding colony at the Biologic Resources Laboratory at the University of Illinois at Chicago was found to have a high serum calcium value (> 12 mg/dl). To determine the cause of the hypercalcemia, additional diagnostic tests, including thoracic and abdominal radiographs and a parathyroid panel (parathyroid hormone (PTH), ionized calcium, and parathyroid hormone-related protein (PTH-rp) assays), were performed. The radiographs did not reveal lesions suggestive of neoplasia.

Inflammatory myofibroblastic tumor presenting with tracheal obstruction in a pregnant woman.

Inflammatory myofibroblastic tumor (IMT), also known as inflammatory pseudotumor, is a benign lesion predominantly found in the lung and abdomen. Sporadic cases have been reported in the trunk, genitourinary tract, and extremities as well as in the head and neck. Of critical importance is this entity's correct histopathologic diagnosis that differentiate it from malignant neoplasms such as spindle cell carcinoma and fibrosarcoma, benign tumors such as neurofibroma, and other pseudoneoplastic lesions such as nodular fasciitis.

Mutational status of overexpressed p16 in head and neck cancer: evidence for germline mutation of p16/p14ARF.

Inactivation of the p16 tumor suppressor gene is a common phenomenon in squamous cell carcinoma of the head and neck (SCCHN). Less commonly described is the observation of p16 overexpression in SCCHN. Since overexpression of p16 is a potent predictor of outcome in other cancers, we were interested in determining the level of expression of p16 in our SCCHN specimens as a prerequisite to later prognostic studies.

Reconstruction of the nasal columella.

Objective: To report techniques successful for nasal columella reconstruction.

Methods: Retrospective medical chart review of patients undergoing columella reconstruction by 2 of us (D.A.

Bilateral lateral rhinotomy incisions for medial maxillectomies in the management of pediatric invasive fungal sinusitis.

Objective: To determine if simultaneous, bilateral lateral rhinotomies for medial maxillectomies would result in central skin or bone loss in pediatric patients with invasive fungal disease.

Study Design: Retrospective chart review.

Setting: Tertiary care children's hospital.

Importance of chin evaluation and treatment to optimizing neck rejuvenation surgery.

The chin is the keystone linking the aesthetics of the face and neck but is often neglected in the analysis. Procedures related to the chin play an important role in defining neck anatomy. Alloplastic implants can provide the illusion of a longer jaw line in a patient with retrogenia.

Reconstruction of large nasal defects.

Large nasal defects resulting from trauma or oncologic resection are a difficult reconstructive challenge, requiring special structural and aesthetic considerations. This article reviews reconstructive options by anatomic site and discusses techniques that address more complex defects, such as those involving multiple aesthetic units.

p16 mutation frequency and clinical correlation in head and neck cancer.

The tumor suppressor gene p16, when altered, has been shown to play a role in oncogenesis in many different tumor types including head and neck cancer. The goal of this study was to analyse alterations to p16 in squamous cell carcinoma (SCC) of the head and neck and to correlate these with clinical outcome. RNA was isolated from 26 SCC head and neck tumors and from 24 matched controls.

Growth factors during endotoxin-induced otitis media.

The presence of growth factors in the middle ear fluid was examined during lipopolysaccharide-induced otitis media (OM) in the chinchilla. There was a progressive significant increase in the proliferative activity detected in the LPS-free MEF by five days in culture. We conclude that lps indirectly mediates hyperproliferative changes in the middle ear during OM by inducing growth factors.

A monoclonal antibody identifies vimentin filaments in Sertoli cells and in a subset of epithelial cells in the rat epididymis, urinary bladder, and prostate.

Purpose: We describe a monoclonal antibody (Mab B2) against vimentin filaments in rat Sertoli cells and in a subset of epithelial cells in the rat epididymis, prostate and urinary bladder.

Materials And Methods: The immunoreactivity of Mab B2 was examined on cryostat sections and immunoblots and compared with the reactivity of a previously characterized monoclonal antibody against vimentin.

Results: While both antibodies recognized vimentin in Sertoli cells, only Mab B2 recognized vimentin in urogenital tract epithelia.

Germ cell binding to rat Sertoli cells in vitro.

The interaction between male germ cells and Sertoli cells was studied in vitro by co-incubation experiments using isolated rat germ cells and primary cultures of Sertoli cells made germ cell-free by the differential sensitivity of germ cells to hypotonic shock. The germ cell/Sertoli cell interaction was examined morphologically with phase-contrast and scanning electron microscopy and then quantified by measuring radioactivity bound to Sertoli cell cultures after co-incubation with added [3H]leucine-labeled germ cells. Germ cell binding to Sertoli cell cultures was the result of specific adhesion between these two cell types, and several features of this specific adhesion were observed.