Publications by authors named "Danae Kokossis"
Article Synopsis
- Focused ultrasound (FUS) combined with microbubbles shows potential for enhancing drug delivery across the blood-brain barrier (BBB) in Alzheimer's disease, but current methods are limited by their reliance on MRI facilities or invasive procedures.
- A pilot study evaluated a new portable system, neuronavigation-guided FUS (NgFUS), in six mild to moderate Alzheimer’s patients, using real-time mapping of microbubble activity to ensure safety and efficacy during treatment.
- Results indicated that BBB opening was achieved in 5 out of 6 subjects, with significant correlations between cavitation dose, BBB opening volume, and increased levels of Alzheimer’s biomarkers, demonstrating the system's capability for real-time monitoring and safety in outpatient settings.
Background: Diffuse midline glioma (DMG) is a pediatric tumor with dismal prognosis. Systemic strategies have been unsuccessful and radiotherapy (RT) remains the standard-of-care. A central impediment to treatment is the blood-brain barrier (BBB), which precludes drug delivery to the central nervous system (CNS).
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- Focused ultrasound (FUS) combined with microbubbles shows potential for opening the blood-brain barrier (BBB) to improve drug delivery in Alzheimer's disease, but current methods are limited to MRI-equipped settings or invasive implants.
- A pilot study involving 6 mild to moderate AD patients tested a new portable, non-invasive NgFUS system that monitored real-time microbubble activity to confirm safety and effectiveness during a single treatment session.
- The results indicated that BBB opening was successfully achieved in 5 out of 6 patients, with significant correlations observed between microbubble activity and BBB opening volume, alongside increases in Alzheimer-related biomarkers in the blood, suggesting effective drug delivery methods can emerge from this technology.