Publications by authors named "Dana Teislerova"

Article Synopsis
  • Tick-borne encephalitis virus (TBEV) poses a significant health threat with no specific treatments available, while mouse monoclonal antibodies show protection against it.* -
  • This study examined the human immune response, finding that individuals who recovered from TBEV infection had the strongest neutralizing antibodies compared to vaccinated individuals.* -
  • The research identified a key structural region in the virus that these powerful antibodies target and demonstrated that low doses of antibodies can effectively treat infected mice.*
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Vaccination against tick-borne encephalitis (TBE) is based on the use of formalin-inactivated, culture-derived whole-virus vaccines. Immune response following vaccination is primarily directed to the viral envelope (E) protein, the major viral surface antigen. In Europe, two TBE vaccines are available in adult and pediatric formulations, namely FSME-IMMUN (Pfizer) and Encepur (GlaxoSmithKline).

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Unlabelled: The Western blot (WB) method was verified for serological diagnosis of chlamydial infections.

Material And Methods: For testing, sera previously examined by the microimmunofluorescence (MIF) test with either ambiguous results or those suggesting persistent infection were used.

Results: Whereas the investigation confirmed adequate sensitivity and specificity of the MIF test for diagnosing Chlamydophila pneumoniae infection, it was less sensitive in case of Chlamydia trachomatis.

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