Clinical and economic impact of meropenem resistance in Pseudomonas aeruginosa-infected patients.

Background: The emergence of carbapenem resistance has had a significant impact on both clinical and economic outcomes.

Methods: A retrospective, observational cohort study was performed in a 433-bed tertiary care medical center. The cohort was established from all inpatients with Pseudomonas aeruginosa-positive cultures over a 3-year period.

Clinical and economic impact of a quality improvement initiative to enhance early recognition and treatment of sepsis.

Background: Studies evaluating the clinical effectiveness of sepsis screening tools and methods to improve the time from diagnosis to antibiotic administration are needed to improve sepsis-related outcomes.

Objective: To evaluate the clinical and economic impact of a sepsis quality improvement initiative to improve early recognition and treatment of sepsis.

Methods: A retrospective observational study of adults with sepsis was performed in a 433-bed tertiary medical center.

Randomized clinical trial of propofol with and without alfentanil for deep procedural sedation in the emergency department.

Objectives: The objectives were to compare the efficacy, occurrence of adverse events, and recovery duration of propofol with and without alfentanil for use in procedural sedation in the emergency department (ED).

Methods: This was a randomized nonblinded prospective trial of adult patients undergoing procedural sedation for painful procedures in the ED. Patients with pain before the procedure were given intravenous (IV) morphine sulfate until their pain was adequately treated at least 20 minutes before starting the procedure.

Continuous versus intermittent infusion of prophylactic cefoxitin after colorectal surgery: a pilot study.

Study Objective: To compare 30-day postoperative surgical site infections (SSIs) and rates of antibiotic discontinuation within 24 hours after surgery in patients receiving continuous-infusion versus intermittent-infusion cefoxitin for postoperative antibiotic prophylaxis.

Design: Retrospective, cohort-matched pilot study.

Setting: Tertiary-care medical center.

Effects of alcohol, personality, and provocation on the expression of anger in men: a facial coding analysis.

Background: Research has demonstrated that alcohol-related aggression is modulated by anger-based personality traits. However, it is unclear how anger, as a concomitant of aggression, is affected by an interaction among these variables. The present study evaluated the effects of alcohol, anger-based traits, and physical provocation on anger.