Publications by authors named "Dana Saipiyeva"
Article Synopsis
- Primary biliary cholangitis (PBC) is a liver and immune system condition, and a study investigated the effects of transplanting autologous bone marrow-derived mononuclear cells (BM-MNCs) in affected patients.
- Sixteen PBC patients underwent BM-MNC harvesting and transplantation between 2017 and 2022, with monitoring of liver function and immune cell changes over time using statistical analyses.
- The results showed significant improvements in liver function tests and notable changes in immune cell populations, suggesting that BM-MNC transplantation could be a promising therapeutic approach for managing PBC.
Background: In this phase I clinical trial, our primary objective was to develop an innovative therapeutic approach utilizing autologous bone marrow-derived mesenchymal stromal/stem cells (BM-MSCs) for the treatment of nonobstructive azoospermia (NOA). Additionally, we aimed to assess the feasibility and safety of this approach.
Materials And Methods: We recruited 80 participants in this non-randomized, open-label clinical trial, including patients undergoing NOA treatment using autologous BM-MSCs (n=40) and those receiving hormone therapy as a control group (n=40).
Stem cells have been introduced as new promising therapeutic agents in treatment of degenerative diseases because of having high differentiation potential while maintaining the ability to self-replicate and retaining features of their source cells. Among different type of cell therapies, mesenchymal stromal/stem cell (MSC) therapy is being increasingly developed as a new way to treat structural defects that need to be repaired and regenerated. Non-obstructive azoospermia (NOA) is a reproductive disease in men that causes infertility in 10% of infertile men.
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