Open globe injuries: Epidemiology, visual and surgical predictive variables, prognostic models, and economic cost analysis.

Background: Open globe injuries (OGI) represent a visually and economically devastating cause of vision loss. We examined the epidemiology, predictive variables, prognostic models, and economic cost of surgically managed OGI.

Methods: A retrospective tertiary centre study from 2008 to 2018 of 155 consecutive OGI in individuals aged 16 and older was performed.

Microbial Keratitis and Ocular Surface Disease: A 5-Year Study of the Microbiology, Risk Factors and Clinical Outcomes in Sydney, Australia.

: To report the microbiological and clinical profiles, and outcomes of patients with microbial keratitis who had ocular surface disease (OSD) at the Sydney Eye Hospital, Australia over a 5-year period.: A retrospective case-series study was conducted. Patients diagnosed with microbial keratitis who had a history of OSD (dry eye, blepharitis, Steven Johnson syndrome (SJS) and ocular cicatricial pemphigoid (OCP)) from 1 January 2012 to 31 December 2016 were identified from hospital coding and pathology data.

Clinical translation of recommendations from randomized trials for management of herpes simplex virus keratitis.

Importance: To standardize initial anti-viral therapy for herpes simplex keratitis (HSK).

Background: To determine prescribing trends for the management of HSK and compare the trends to available clinical trial evidence.

Design: Retrospective review of patients at the Sydney Eye Hospital, Australia.

Corneal biopsy for diagnosis of recalcitrant microbial keratitis.

Purpose: To document the findings of corneal biopsies for progressive microbial keratitis in a large tertiary referral institution.

Methods: A retrospective medical records review of all patients who underwent at least one corneal biopsy for the diagnosis of microbial keratitis at Sydney Eye Hospital, Australia between January 1, 2010 and December 31, 2016 was performed.

Results: Thirty-eight patients (18 men and 20 women) underwent a corneal biopsy for progressive microbial keratitis unresponsive to broad-spectrum topical antimicrobials.

keratitis in 194 patients: risk factors for bad outcomes and severe inflammatory complications.

Background/aims: To determine demographic and clinical features of patients with keratitis (AK) that are independent risk factors both for bad outcomes and for severe inflammatory complications (SIC).

Methods: A retrospective audit of medical records of AK cases at Moorfields Eye Hospital from July 2000 to April 2012, including 12 earlier surgical cases. Cases with a bad outcome were defined as those having one or more of the following: corneal perforation, keratoplasty, other surgery (except biopsy), duration of antiamoebic therapy (AAT) ≥10.

The Impact of Topical Corticosteroids Used in Conjunction with Antiamoebic Therapy on the Outcome of Acanthamoeba Keratitis.

Purpose: To examine the impact of topical corticosteroid use after the start of antiamoebic therapy (AAT) on the outcomes of Acanthamoeba keratitis (AK) therapy.

Design: Cohort study.

Participants: A total of 196 patients diagnosed with AK at Moorfields Eye Hospital, London, between January 1991 and April 2012.

Established and emerging ancillary techniques in management of microbial keratitis: a review.

Microbial keratitis is a sight-threatening condition and an ocular emergency, because of the potential for rapid progression. Intensive topical antimicrobials are the mainstay and the gold standard of treatment for microbial keratitis. However, despite appropriate diagnosis and therapy, treatment failure is still common, and can result in significant morbidity due to corneal perforation and/or scarring.

Central toxic keratopathy after laser in situ keratomileusis.

Purpose: To review cases of central toxic keratopathy (CTK) occurring over a period of 46 days.

Setting: Moorfields Eye Hospital, London, United Kingdom.

Design: Retrospective consecutive case series.

Therapeutic and optical keratoplasty in the management of Acanthamoeba keratitis: risk factors, outcomes, and summary of the literature.

Objective: To report the risk factors for and outcomes of therapeutic and optical keratoplasty in the management of Acanthamoeba keratitis (AK).

Design: Retrospective case series.

Participants: A total of 50 eyes of 196 patients with retrievable medical records, diagnosed with AK at Moorfields Eye Hospital, London, underwent keratoplasty between January 1991 and April 2012.

The impact of topical corticosteroid use before diagnosis on the outcome of Acanthamoeba keratitis.

Objective: To examine the impact of topical corticosteroid use before the diagnosis of Acanthamoeba keratitis (AK) on final visual outcomes and to determine the prognostic factors predicting poorer outcomes.

Design: Cohort study.

Participants: A total of 209 eyes of 196 patients with retrievable medical records, diagnosed with AK at Moorfields Eye Hospital, London, between January 1991 and April 2012.

A case of subacute cutaneous lupus erythematosus as a result of ranibizumab (Lucentis) treatment.

Cutaneous lupus erythematosus is a previously undiagnosed side-effect of ranibizumab. Here, we present a case of an 82-year-old female Caucasian patient with wet age-related macular degeneration. Following a single intraocular injection of Lucentis (ranibizumab), she developed a subacute cutaneous lupus erythematosus which, with treatment, took nearly 12 months to resolve.

Socio-economic, familial and perinatal factors associated with obesity in Sydney schoolchildren.

Aim: To examine associations between socio-economic, familial and perinatal factors with overweight/obesity in 6- and 12-year-old schoolchildren.

Methods: Eligible year-1 (1765/2238, mean age 6.7 years) and year-7 students (2353/3144, mean age, 12.

Evidence of arteriolar narrowing in low-birth-weight children.

Background: Cardiovascular disease may have its origins in utero, but the influence of in utero growth on microvascular structure in children is unknown. We hypothesized that poor in utero growth is associated with narrower arteriolar caliber, which may help explain the established association of low birth weight with hypertension and cardiovascular disease in adulthood.

Methods And Results: We examined the relation of birth weight and other markers of in utero growth to microvascular caliber in the retina in a population-based study of 1369 6-year-old children in Sydney, Australia (Sydney Childhood Eye Study).

Prevalence of hyperopia and associations with eye findings in 6- and 12-year-olds.

Purpose: To describe the prevalence of hyperopia and associated factors in a representative sample of Australian schoolchildren 6 and 12 years old.

Design: Population-based cross-sectional study.

Participants: Schoolchildren ages 6 (n = 1765) and 12 (n = 2353) from 55 randomly selected schools across Sydney.

Ethnic differences in the impact of parental myopia: findings from a population-based study of 12-year-old Australian children.

Purpose: To examine the influences of ethnicity, parental myopia, and near work on spherical equivalent refraction (SER) and axial length (AL) in a population-based sample of 12-year-old Australian children.

Methods: Year-7 children in the Sydney Myopia Study (n = 2353, 75.3% response) underwent an ophthalmic examination including cycloplegic autorefraction (1% cyclopentolate) and ocular biometry (IOLMaster; Carl Zeiss Meditec GmbH, Jena, Germany).

Can information on the purpose of spectacle use and age at first use predict refractive error type?

Purpose: To assess the sensitivity and specificity of predicting refractive error type using information from a four-item questionnaire on the purpose of spectacle use and age at first use.

Methods: The Sydney Myopia Study examined 1,740 year 1 (78.9% response) and 2,353 year 7 students (75.

Stereoacuity and ocular associations at age 12 years: findings from a population-based study.

Purpose: To report the distribution of stereoacuity thresholds and ocular characteristics associated with reduced stereoacuity in a representative sample of 12-year-old Australian children.

Methods: Stereoacuity thresholds were determined using the three quantitative plates of the TNO test in 2343 children, either unaided or with spectacles, if worn. Logarithm of minimum angle of resolution (logMAR) visual acuity was measured.

Factors associated with a previous diagnosis of strabismus in a population-based sample of 12-year-old Australian children.

Purpose: To describe the prevalence of strabismus and factors associated with its diagnosis in a representative sample of older Australian children.

Design: Cross-sectional, population-based study.

Methods: A representative stratified random cluster sample of 2353 children (aged 12 years) attending 21 secondary schools in Sydney, Australia was examined in 2004 to 2005 (response 75.

Prevalence of eye disorders in young children with eyestrain complaints.

Purpose: To determine whether eyestrain symptoms predict eye conditions in 6-year-old children.

Design: Cross-sectional population-based study.

Methods: Reports of eyestrain symptoms were sought in parental questionnaires; 1740 children (79% response) underwent eye examinations (visual acuity, cover testing, cycloplegic autorefraction, and fundus examination).

Refractive error and patterns of spectacle use in 12-year-old Australian children.

Purpose: To document the prevalence of visual impairment resulting from refractive error and to describe patterns of spectacle use in a representative sample of 12-year-old Australian school children.

Design: Population-based cross-sectional study.

Participants: Two thousand three hundred fifty-three predominantly 12-year-old children examined from 2004 through 2005.

Patterns of eyecare utilization by young Australian children: findings from a population-based study.

Objectives: To report factors associated with childhood eyecare utilization in a random sample of 1740 Sydney schoolchildren aged 6, examined during 2003-4.

Methods: Information on use of eyecare services, defined as any previous consultation with an ophthalmologist or optometrist, was sought from parents. Children had comprehensive eye examinations, including visual acuity (VA), cover testing, cycloplegic refraction and dilated fundus examination.