Publications by authors named "Dana R Hodorovich"
Article Synopsis
- The larval zebrafish model is valuable across various research fields, especially in studying neuropsychiatric, developmental, and toxicological behaviors through behavioral analysis.
- A study investigated how different testing arena sizes and embryo media affect key behaviors like acoustic startle sensitivity and locomotion in zebrafish larvae, finding that larger arenas reduce startle sensitivity and increase movement.
- Specific components in embryo media also significantly influenced behaviors, and rearing mutant zebrafish for CHARGE syndrome in various media showed changes in observed phenotypes, highlighting the need for standardized approaches in zebrafish behavioral studies.
Article Synopsis
- The larval zebrafish is a versatile model for research in various fields, but there is a need for standardized behavioral analysis due to how experimental factors can influence results.
- Testing different arena sizes and types of embryo media revealed that larger arenas lead to reduced startle sensitivity and increased overall movement, while specific media components negatively affected various behavioral responses.
- Understanding these influences allows researchers to choose optimal conditions for their experiments, improving the reliability of findings, especially in genetic and chemical screening studies.
CHARGE syndrome is a heterogeneous disorder characterized by a spectrum of defects affecting multiple tissues and behavioral difficulties such as autism, attention-deficit/hyperactivity disorder, obsessive-compulsive disorder, anxiety, and sensory deficits. Most CHARGE cases arise from de novo, loss-of-function mutations in chromodomain-helicase-DNA-binding-protein-7 (CHD7). CHD7 is required for processes such as neuronal differentiation and neural crest cell migration, but how CHD7 affects neural circuit function to regulate behavior is unclear.
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