Publications by authors named "Dana McQueen"
Objective: To evaluate the association between embryo transfer techniques and pregnancy outcomes.
Design: This is a prospective observational study with a retrospective cohort.
Setting: University Clinic.
This manuscript reports on the prevalence of early pregnancy loss. The impact of improved pregnancy diagnosis and influence of increased age and body mass index at first birth are discussed.
View Article and Find Full Text PDFEmbryo transfer (ET) is considered as a critical step in the process of in vitro fertilization. Interestingly, studies have consistently shown significant outcome differences between physicians. Although the outcome of ET is not related to the physician's experience and specifically not different between fellows and attending physicians, certain techniques have been found to affect the success rate.
View Article and Find Full Text PDFThe objective of this study was to evaluate prevalence of chronic endometritis in a cohort of patients with retained pregnancy tissue (RPT) following miscarriage, with and without a history of recurrent pregnancy loss (RPL). In a cohort of our single academic fertility centre, we evaluated women with unexplained RPL (two or more losses) without evidence of RPT and women undergoing hysteroscopic resection of RPT following miscarriage. Endometrial samples underwent staining with H and E and CD138.
View Article and Find Full Text PDFObjective: To determine if there is a relationship between paternal factors and embryonic aneuploidy of paternal origin using preimplantation genetic testing for aneuploidy (PGT-A).
Design: Retrospective cohort.
Setting: Academic.
Objective: To evaluate the relationship between maternal body mass index (BMI) and embryonic aneuploidy of maternal origin.
Design: Retrospective cohort analysis.
Setting: University hospital-based reproductive center.
Objective: To assess the relationship between maternal body mass index (BMI) and embryo morphokinetics on time-lapse microscopy (TLM).
Design: Retrospective cohort study.
Methods: All IVF cycles between June 2015 and April 2017 were reviewed.
Article Synopsis
- The study looked at how a mother's weight (BMI) might be linked to having repeated miscarriages.
- Researchers reviewed a lot of studies and data from over 3,800 women who had experienced repeated miscarriages and compared them to over 4,000 women who hadn't.
- The results showed that women with a history of miscarriages generally had a higher BMI than those who didn't, suggesting that weight could be a factor in pregnancy issues.
Article Synopsis
- The study focused on using a special DNA test to see if ectopic pregnancies (when a pregnancy happens outside the uterus) have extra or missing chromosomes (aneuploidy).* -
- Researchers looked at tissues from women who had surgery for ectopic pregnancies and found that the DNA in the samples was normal (euploid), meaning they didn't have those extra or missing chromosomes.* -
- Although the results were good, the scientists say more research is needed to understand why ectopic pregnancies happen and if this DNA test can be used more widely in the future.*
Purpose: The purpose of this study is to evaluate the perspectives of infertility patients regarding genetic carrier screening, embryo sex selection, embryo research, and gene editing.
Methods: An anonymous 32-question survey was distributed electronically to all patients who seen at a single academic fertility center for at least one visit between June 2018 and September 2019. Survey questions evaluated patient perspectives on genetic carrier screening, embryo sex selection, embryo research, and gene editing.
Article Synopsis
- Scientists are trying to figure out how to diagnose a condition called chronic endometritis and see if it happens more in women who have many pregnancy losses compared to those who don’t.!
- They took tissue samples from women who had experienced repeated pregnancy losses and from women without that history to compare the results.!
- The study found that a lot more women with repeated losses had signs of chronic endometritis, suggesting that this condition might be linked to why they keep losing pregnancies.!
Psychological distress and postponed fertility care during the COVID-19 pandemic.
J Assist Reprod Genet
February 2021
Purpose: To evaluate perceptions of delayed fertility care secondary to the COVID-19 pandemic.
Methods: This was a cross-sectional anonymous survey of N = 787/2,287 patients (response rate = 42.6%) from a single academic fertility center.
Objective: To use time-lapse imaging to compare embryo morphokinetic parameters between embryos resulting in euploid pregnancy loss and euploid embryos resulting in live birth.
Design: Retrospective cohort study.
Setting: Single academic fertility center.
Article Synopsis
- * Researchers conducted an observational study involving 115 women, analyzing the gestational age (GA) based on LH surge, LMP, and the first measurable crown-rump length (CRL).
- * Results indicated that the LH surge correlated better with CRL, suggesting it's a more reliable method for early pregnancy dating than the LMP.
Objective: To evaluate current national practices in embryo transfer (ET) training in United States reproductive endocrinology and infertility (REI) fellowship programs and live birth rates after ET performed by fellows versus attending physicians.
Design: Cross-sectional survey of U.S.
Objective: To summarize current understanding of the effects of novel and prior coronaviruses on human reproduction, specifically male and female gametes, and in pregnancy.
Design: Review of English publications in PubMed and Embase to April 6, 2020.
Method(s): Articles were screened for reports including coronavirus, reproduction, pathophysiology, and pregnancy.
Research Question: Is minority race associated with worse oocyte donation outcomes?
Design: Retrospective analysis of 926 oocyte recipients who underwent a donor cycle with fresh embryo transfer at a single fertility centre between January 2009 and June 2015. Race was self-reported. To adjust for repeat donors within the sample, mixed models were used to analyse donor parameters and recipient outcomes.
Objective: To investigate the rate of sperm DNA fragmentation in male partners of women with recurrent pregnancy loss and fertile control women.
Design: Systematic review and meta-analysis.
Setting: Not applicable.
Objective: To characterize the available support for infertility treatment and populations served by private foundations across the United States.
Design: Web-based cross-sectional survey.
Setting: Not applicable.
Rapid advances in genomics have expanded the use of chromosome testing following miscarriage. In addition to conventional cytogenetics, the availability of single nucleotide polymorphism microarray technology and array comparative geneomic hybridization have provided further options for clinicians. This review will cover the indications for testing and the advantages/disadvantages of the various methodologies available.
View Article and Find Full Text PDFObjective: To determine whether an association exists between maternal antithyroid antibodies and euploid miscarriage in women with recurrent early pregnancy loss (REPL).
Design: Observational cohort study.
Setting: Two academic medical centers.