Publications by authors named "Dana McCormack"
Article Synopsis
- * By employing single-nucleus RNA sequencing, researchers analyzed over 170,000 astrocyte nuclei across different developmental stages and brain areas in mice and marmosets, revealing distinct regional differences in astrocyte gene expression that are not shared with neurons or other glial cells.
- * The study found that while astrocytes show regional patterns even in late embryonic stages, their gene expression changes significantly after birth for specialization, with differences in gene expression and maturation timing observed between the two species studied. *
Article Synopsis
- Researchers examined over 2.4 million brain cells from 18 locations in the common marmoset using single-nucleus RNA sequencing to analyze gene expression patterns in various brain structures.
- The findings suggest that the adult identity of most neuron types is influenced more by their developmental origins than by the types of neurotransmitters they release.
- High proportions of specific neuron types were found in higher-order cortical areas, and the study utilized cell type-specific enhancers and AAV-GFP to visualize different interneuron morphologies in the neocortex and striatum.
