Publications by authors named "Dana Marten"
Article Synopsis
- MSCs are valuable for cell therapies and tissue engineering, with bone marrow being the primary source, yet it has drawbacks like low cell frequency and painful extraction.
- Researchers are exploring the human umbilical cord (UC) as an alternative source since it is easily accessible and poses no ethical issues.
- UC-derived cells have characteristics similar to bone marrow MSCs, show greater availability, and possess unique immune-modulatory properties that could enhance their clinical applications.
Because the regeneration of large bone defects is limited by quantitative restrictions and risks of infections, the development of bioartificial bone substitutes is of great importance. To obtain a three-dimensional functional tissue-like graft, static cultivation is inexpedient due to limitations in cell density, nutrition and oxygen support. Dynamic cultivation in a bioreactor system can overcome these restrictions and furthermore provide the possibility to control the environment with regard to pH, oxygen content, and temperature.
View Article and Find Full Text PDF