Publications by authors named "Dana MacFarlane"
Article Synopsis
- Recent advancements in human genetics have greatly enhanced our understanding of rheumatic and autoimmune diseases, identifying numerous genetic loci and variants linked to these conditions.
- Despite these discoveries, pinpointing the specific genetic variations that cause diseases and how they operate remains a challenge, especially with variants located in non-coding regions of the genome.
- The emergence of genome editing technologies like CRISPR-Cas offers new methods to explore and clarify the mechanisms behind these genetic risks, paving the way for improved therapeutic strategies in autoimmune diseases.
Interventions that stimulate and engage individuals with dementia physically, cognitively, and socially offer promise for improving health and well-being and for potentially slowing functional losses with disease progression. We describe a volunteer-based intervention that combines physical exercise, cognitive-linguistic stimulation, and social outings for older persons living with dementia in rural communities. One-year follow-up data, although clearly preliminary (n = 8), suggest stability in global cognition, mood, and aspects of physical fitness.
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