Tamoxifen induces regression of estradiol-induced mammary cancer in the ACI.COP-Ept2 rat model.

The ACI rat is a unique model of human breast cancer in that mammary cancers are induced by estrogen without carcinogens, irradiation, xenografts or transgenic manipulations. We sought to characterize mammary cancers in a congenic variant of the ACI rat, the ACI.COP-Ept2.