Publications by authors named "Dana J Clanton"
Article Synopsis
- Colon cancer likely originates from normal colon stem cells, with CD44 identified as a marker for colon cancer stem cells similar to its role in breast and prostate cancer.
- CD44(hi) colon tumor cells showed significantly greater tumorigenic potential in mouse models, forming tumors with much fewer cells compared to CD44(-) cells, indicating a strong self-renewal capacity.
- CD44(hi) cells also displayed characteristics of slow division and were enriched for key nuclear markers related to tumor progression, suggesting further research is needed to enhance the identification and isolation of colon cancer stem cells.
