Optimal treatment of obesity-related hypertension: the Hypertension-Obesity-Sibutramine (HOS) study.

Background: Current guidelines for the treatment of hypertension do not provide specific recommendations for obese hypertensive patients. To identify an optimal treatment regimen for obese hypertensive patients, we studied the interactions between a drug-based weight loss approach by sibutramine and different antihypertensive drug regimens.

Methods And Results: This was a prospective, 16-week double-blind placebo-controlled randomized multicenter study in 171 obese hypertensive patients.