Plasma-type gelsolin is decreased in human blood and cerebrospinal fluid after subarachnoid hemorrhage.

Background And Purpose: Subarachnoid hemorrhage (SAH) pathophysiology involves neurovascular proteolysis and inflammation. How these 2 phenomena are related remains unclear. We hypothesize that matrix metalloproteinases (MMPs) mediate the depletion of anti-inflammatory plasma-type gelsolin (pGSN).