Publications by authors named "Dana Elena Mitrica"
Nonalcoholic fatty liver disease (NAFLD) currently represents one of the most common liver diseases worldwide. Early diagnosis and disease staging is crucial, since it is mainly asymptomatic, but can progress to nonalcoholic steatohepatitis (NASH) or cirrhosis or even lead to the development of hepatocellular carcinoma. Over time, efforts have been put into developing noninvasive diagnostic and staging methods in order to replace the use of a liver biopsy.
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- - Hepatocellular carcinoma (HCC) is a major cause of cancer deaths globally, and the study focuses on the decreasing role of alpha-fetoprotein (AFP) as a biomarker compared to imaging studies and new biomarkers.
- - The research involved 131 newly diagnosed HCC patients, analyzing the relationship between elevated AFP levels and various tumor and liver features, using a cut-off level of 200 IU/mL.
- - Results indicated that a tumor size greater than 5 cm is a significant predictor of elevated AFP levels, along with other factors like tumor type and portal vein thrombosis, suggesting that AFP may still be a useful tool in certain contexts, particularly in developing countries.