Importance of thiopurine S-Methyltransferase gene polymorphisms for prediction of azathioprine toxicity.

Objectives: Our study aims to find the relationship between metabolic enzyme thiopurine S-methyltransferase (TPMT) gene polymorphisms and clinical output of the therapy with azathioprine. We focused on patients who experienced leucopenia caused by high blood levels of active azathioprine metabolites.

Design: Our group consists of 87 patients who have been treated by azathioprine.