Intracranial injection of AAV expressing NEP but not IDE reduces amyloid pathology in APP+PS1 transgenic mice.

The accumulation of β-amyloid peptides in the brain has been recognized as an essential factor in Alzheimer's disease pathology. Several proteases, including Neprilysin (NEP), endothelin converting enzyme (ECE), and insulin degrading enzyme (IDE), have been shown to cleave β-amyloid peptides (Aβ). We have previously reported reductions in amyloid in APP+PS1 mice with increased expression of ECE.

Traumatic ventricular septal defect: characterization with electrocardiogram-gated cardiac computed tomography angiography.

Ventricular septal defects as a result of blunt trauma to the chest have not been frequently reported in the literature. In addition, the majority of these cases have been imaged with echocardiography alone. We report a case in which a ventricular septal defect caused by blunt chest trauma was characterized with electrocardiogram-gated computed tomography angiography.