Neuroschistosomiasis in Young Filipino Patient Presenting with Seizure.

Unlabelled: Neuroschistosomiasis, a rare manifestation of schistosomiasis affecting the central nervous system (CNS), can result in severe neurological complications if not promptly diagnosed and treated. The condition arises due to the development of granulomas around eggs that become lodged within the CNS. Here we present a case report involving a young Filipino individual who had recurrent, uncontrolled seizures, ultimately attributed to neuroschistosomiasis.

Do modern family planning methods impact women's quality of life? Jordanian women's perspective.

Background: Although Jordan has made progress in meeting Family Planning (FP) needs in last decades, recently the use of FP methods has declined significantly. Women's personal experiences, knowledge, and perceptions of how a FP method might impact their quality of life (QoL) can influence FP decisions. However, a lack of comprehensive understanding of the impact of modern FP methods on women's QoL continues to exist among Jordanian couples.

Assessing nicotine dependence using an oral nicotine free-choice paradigm in mice.

Models to assess the addictive-like properties of nicotine in mice are limited. Therefore, we aimed to characterize and validate an addiction index by using an oral nicotine free-choice paradigm in mice. Adult C57BL/6J, DBA/2J, or genetically modified mice carrying deletions for nicotinic acetylcholine receptor (nAChR) subunits, (n = 8-10/sex/group) were given a choice of water or nicotine (10-960 μg/ml) solution using a two-bottle free-choice (2BC) paradigm.

Metformin exerts anti-inflammatory effects on mouse colon smooth muscle cells in vitro.

Inflammatory bowel disease (IBD) is a chronic incurable condition characterized by relapsing inflammation of the gut. Intestinal smooth muscle cells (SMCs) are affected structurally and functionally during IBD due to excessive production of different inflammatory mediators. Metformin is a widely used antidiabetic agent known to exert several anti-inflammatory effects in different tissues independently from its hypoglycemic effect.