DKK3 ameliorates neuropathic pain via inhibiting ASK-1/JNK/p-38-mediated microglia polarization and neuroinflammation.

Background: Neuropathic pain is a common and severely disabling state that affects millions of people worldwide. Microglial activation in the spinal cord plays a critical role in the pathogenesis of neuropathic pain. However, the mechanisms underlying spinal microglial activation during neuropathic pain remain incompletely understood.

Effects of microplastics on lentil (Lens culinaris) seed germination and seedling growth.

Widespread use of plastics and mishandling has resulted in severe environmental issues affecting seed germination and seedling growth. This study investigates the effect of polyethylene microplastics (740-4990 nm PEMPs) on lentil (Lens culinaris) seed germination and seedling growth using Biospeckle Optical Coherence Tomography (bOCT), a technique that we successfully demonstrated earlier in visualizing the internal activity of plants. Lentil seeds were exposed to PEMPs bioassay for seven days with 10, 50, and 100 mg L concentrations.

Effect of Attentional Focus on Sprint Performance: A Meta-Analysis.

Sprinting is often seen in a variety of sports. Focusing one's attention externally before sprinting has been demonstrated to boost sprint performance. The present study aimed to systematically review previous findings on the impact of external focus (EF), in comparison to internal focus (IF), on sprint performance.

MiR-379-5p inhibits the proliferation, migration, and invasion of breast cancer by targeting KIF4A.

Background: Many studies have shown that microRNAs (miRNAs) play an essential role in gene regulation and tumor development. This study aimed to explore the expression of miR-379-5p and its mechanisms of affecting proliferation, migration, and invasion in breast cancer (BC).

Methods: MiRNAs and mRNAs expression data of BC and normal breast tissue samples were downloaded from the TCGA and GEO databases.

Can ambient odors influence the recognition of emotional words? A behavioral and event-related potentials study.

Odor context can affect the recognition of facial expressions. However, there is no evidence to date that odor can regulate the processing of emotional words conveyed by visual words. An emotional word recognition task was combined with event-related potential technology.

Studies on the Transmission of a Tigecycline Resistance-Mediating (A) Gene Variant from Enterobacter hormaechei via a Two-Step Recombination Process.

To investigate the contribution of a (A) variant to tigecycline resistance in Enterobacter hormaechei and the recombination events that occurred during transmission of this variant. MICs were determined by broth microdilution. G17 was characterized by PCR, transfer assay, S1-PFGE, Southern blot hybridization, and WGS analysis.

LncRNA , a Ferroptosis Suppressor and Prognositic Signature for GBM.

is a long noncoding RNA also known as long intergenic nonprotein coding RNA 1272 (). The known reports showed that functions as an onco-lncRNA or a suppressor lncRNA by suppressing miRNA in colorectal cancer, gastric cancer and lung cancer. In this study, we first found that , as an onco-lncRNA, alleviates the ferroptosis driven by mutant and promotes mutant -mediated GBM proliferation.

Fibrinogen A Alpha-Chain Amyloidosis in Two Chinese Patients.

Objectives: Fibrinogen A alpha-chain amyloidosis (AFib amyloidosis) is the most common form of hereditary renal amyloidosis in the United Kingdom and Europe, but has rarely been reported in Asia. In this study, we reported two AFib amyloidosis patients in China, reviewing the literature and summarizing main characteristics of AFib amyloidosis in Asia.

Methods: Two unrelated Chinese patients were diagnosed with AFib amyloidosis by clinical presentation, renal biopsy, mass spectrometry and DNA sequencing in Peking University First Hospital of China from 2014 to 2016.

Expression and Regulatory Network Analysis of Function of Small Nucleolar RNA Host Gene 4 in Hepatocellular Carcinoma.

Background And Aims: Long non-coding RNA small nucleolar RNA host genes (SNHGs) play a critical role in the occurrence and development of tumors. In this study, we aimed to investigate the role of in hepatocellular carcinoma (HCC) and its underlining mechanism.

Methods: Datasets were acquired from The Cancer Genome Atlas (TCGA) database.

Mechanism and application of exosomes in the wound healing process in diabetes mellitus.

Poor wound healing can seriously affect the health of patients with diabetes and result in a heavy medical burden. Recently, exosomes have been considered the key substances involved in the healing of diabetic wounds. The important cells related to the process of diabetic wound healing include endothelial cells (ECs), fibroblasts, macrophages, and keratinocytes.

An Atypical Case of Monomicrobial Septicemia With No Gastrointestinal Manifestations.

An uncommon case of monomicrobial septicemia in a 63-year-old man was reported in Zhejiang, China. Once diagnosed, vancomycin treatment cleared the infections. The patient had no remarkable medical history, and the inspection showed no overt gastrointestinal symptoms, though was detected in his stool samples.

Environmental thallium exposure and the risk of early embryonic arrest among women undergoing in vitro fertilization: thallium exposure and polymorphisms of mtDNA gene interaction and potential cause exploring.

Early embryonic arrest (EEA) leads to cancelation of fresh cycles among infertile women undergoing in vitro fertilization (IVF), bringing a great challenge for IVF. Whether exposure to thallium (Tl) is associated with an increased risk of EEA, especially its interaction with polymorphisms of mitochondria DNA (mtDNA) gene, is worthy of study. A case-control design was performed, including 74 EEA cases with 123 IVF cycles and 157 age and BMI-matched controls with 180 IVF cycles.

Macrophage SCAP Contributes to Metaflammation and Lean NAFLD by Activating STING-NF-κB Signaling Pathway.

Background & Aims: Sterol regulatory element binding protein cleavage-activating protein (SCAP) is a cholesterol sensor that confers a broad range of functional effects in metabolic diseases. Lean nonalcoholic fatty liver disease (NAFLD) is characterized by a decrease in subcutaneous fat and ectopic fat deposition in the liver. SCAP may mediate the development of lean NAFLD, but the mechanism of action remains unclear.

Cholesterol sensor SCAP contributes to sorafenib resistance by regulating autophagy in hepatocellular carcinoma.

Background: Hepatocellular carcinoma (HCC) is one of the most malignant tumors and the fourth leading cause of cancer-related death worldwide. Sorafenib is currently acknowledged as a standard therapy for advanced HCC. However, acquired resistance substantially limits the clinical efficacy of sorafenib.

Polysaccharide-Based Hydrogels for Wound Dressing: Design Considerations and Clinical Applications.

Wound management remains a worldwide challenge. It is undeniable that patients with problems such as difficulties in wound healing, metabolic disorder of the wound microenvironment and even severely infected wounds always suffer great pain that affected their quality of lives. The selection of appropriate wound dressings is vital for the healing process.

Spectroscopic characterization of two boron heterocyclic radicals in the solid neon matrix.

Two novel boron heterocyclic radicals, a 3,4,5-trihydroborinine radical and a 1-methyl-2-dihydro-1-borole radical, were observed in the reaction of boron atom with cyclopentene. These radicals were trapped in solid neon and identified using matrix isolation infrared spectroscopy as well as quantum chemical calculations. The ground-state boron atom selectively inserts into the CC double bond of cyclopentene forming a 3,4,5-trihydroborinine radical (A).

TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile.

The emergence of hypervirulent clade 2 Clostridioides difficile is associated with severe symptoms and accounts for >20% of global infections. TcdB is a dominant virulence factor of C. difficile, and clade 2 strains exclusively express two TcdB variants (TcdB2 and TcdB4) that use unknown receptors distinct from the classic TcdB.

Optical design and pupil swim analysis of a compact, large EPD and immersive VR head mounted display.

Virtual reality head-mounted displays (VR-HMDs) are crucial to Metaverse which appears to be one of the most popular terms to have been adopted over the internet recently. It provides basic infrastructure and entrance to cater for the next evolution of social interaction, and it has already been widely used in many fields. The VR-HMDs with traditional aspherical or Fresnel optics are not suitable for long-term usage because of the image quality, system size, and weight.

Mass Spectrometry and Cryogenic Electron Microscopy Illuminate Molecular-Level Mechanisms of the Oxidative and Structural Damage to Lipid Membranes by Radical-Bearing Graphene Oxide.

Biomedical applications of graphene in tumor and bacterial treatment have become cutting-edge fields due to its unique physical and chemical properties. However, a mechanistic understanding of the interactions and reactions between graphene-based material and biological systems such as lipid membranes remains elusive, especially at the molecular level. By using the unique field-induced droplet ionization mass spectrometry and cryogenic electron microscopy methodologies, we reveal the oxidation products of monolayer lipid membranes at the air-water interface and the change in the morphology of bilayer lipid membranes in an aqueous solution caused by the incorporation of graphene oxide bearing π-conjugated carbon radicals [hydrated graphene oxide (hGO)].

Integrated analysis of differentially expressed genes and a ceRNA network to identify hub lncRNAs and potential drugs for multiple sclerosis.

Objective: Multiple sclerosis (MS) is an autoimmune neuroinflammatory disease of the nervous system. However, the precise molecular mechanisms underlying MS have yet to be fully elucidated. In this study, our aim was to provide novel insight into the pathogenesis of MS and provide a resource for identifying new biomarkers and therapeutics for MS.

Effect of Al Addition on Grain Refinement and Phase Transformation of the Mg-Gd-Y-Zn-Mn Alloy Containing LPSO Phase.

The effect of 0−1.0 at.% Al additions on grain refinement and phase transformation of the Mg-2.

The Histone Acetyltransferase MOF Regulates SIRT1 Expression to Suppress Renal Cell Carcinoma Progression.

Background: Renal cell carcinoma (RCC) is one of the most common and lethal human urological malignancies around the world. Although many advancements in diagnostic and therapeutic strategies have been acquired, the prognosis of patients with metastatic RCC was poor. Thus, there is an urgent need to understand the molecular mechanism of RCC.

Functional Polyaniline/MXene/Cotton Fabrics with Acid/Alkali-Responsive and Tunable Electromagnetic Interference Shielding Performances.

Although two-dimensional transition-metal carbides (MXenes) and intrinsic conductive polymers have been combined to produce functional electromagnetic interference (EMI) shielding composites, acid/alkali-responsive EMI shielding textiles have not been reported. Herein, electrically conductive polyaniline (PANI)/MXene/cotton fabrics (PMCFs) are fabricated by an efficient vacuum filtration-assisted spray-coating method for acid/alkali-responsive and tunable EMI shielding applications on the basis of the high electrical conductivity of MXene sheets and the acid/alkali doping/de-doping feature of PANI nanowires. The as-prepared PMCF exhibits a sensitive ammonia response of 19.

The associations of serum metals concentrations with the intermediate and pregnancy outcomes in women undergoing in vitro fertilization (IVF).

Background: Toxic and essential trace elements are reported to have impact on female fertility. However, studies on the potential synergistic or antagonistic effects of metal mixtures on IVF outcomes remain limited.

Objective: To evaluate whether serum concentrations of metals, individually and as mixtures, are associated with pregnancy outcomes in women undergoing IVF.