Natural killer cells in cancer immunotherapy.

Natural killer (NK) cells, as innate lymphocytes, possess cytotoxic capabilities and engage target cells through a repertoire of activating and inhibitory receptors. Particularly, natural killer group 2, member D (NKG2D) receptor on NK cells recognizes stress-induced ligands-the MHC class I chain-related molecules A and B (MICA/B) presented on tumor cells and is key to trigger the cytolytic response of NK cells. However, tumors have developed sophisticated strategies to evade NK cell surveillance, which lead to failure of tumor immunotherapy.

Stereoisomeric coordination polymers based on facial and meridional six-coordinate dysprosium(III ).

Due to the small differences in the chemical properties of () and () stereoisomers, selective synthesis of one of the isomers is challenging, especially for lanthanide complexes. By using a flexible bidentate phosphine oxide ligand, we managed to isolate three stereoisomeric 2D and 3D coordination polymers, in which six-coordinate Dy(III) ions possess - or -ClO coordination environments. Structural studies indicate that the stereochemistry differences result from their various supramolecular interactions (, hydrogen bonding and π⋯π stacking).

[Treatment of extensive cervicomandibular scar in children and adolescent patients with bilateral expanded scapular flaps: report of 7 consecutive cases].

Purpose: To explore the feasibility of applying bilateral free expanded scapular flaps to treat extensive cervicomandibular scar in children and adolescents.

Methods: This study reviewed 7 children and adolescent patients who received bilateral expanded scapular flaps to treat extensive cervicomandibular scars in the Pediatric Plastic Surgery Ward from August 2018 to December 2020. The scars in all patients involved neck, mandible, and anterior chest.

Phosphine Oxide Ligand Based Tetrahedral Co Complexes with Field-induced Slow Magnetic Relaxation Behavior Modified by Terminal Ligands.

Two isostructural mononuclear Co complexes, [Co(xantpo)(NCE) ] (E=S (1) and O (2); xantpo=9,9-dimethyl-4,5-bis(diphenylphosphoryl) xanthene), supported by a bidentate phosphine oxide ligand are reported. The cobalt complexes exhibit characteristic tetrahedral structures coordinated with two oxygen and two nitrogen atoms. Magnetic property measurements show their similar static magnetic behaviours but very different dynamic magnetic behaviours.

A model of sequential heart and composite tissue allotransplant in rats.

Background: Some of the 600,000 patients with solid organ allotransplants need reconstruction with a composite tissue allotransplant, such as the hand, abdominal wall, or face. The aim of this study was to develop a rat model for assessing the effects of a secondary composite tissue allotransplant on a primary heart allotransplant.

Methods: Hearts of Wistar Kyoto rats were harvested and transplanted heterotopically to the neck of recipient Fisher 344 rats.

[Anatomy and clinical application of posterior calf fasciocutaneous flap].

Objective: To investigate the blood supply and the clinical application of the posterior calf fasciocutaneous flap for repairing the frontal defect of knee joint.

Methods: Based on the article review and the anatomical study of the posterior calf in 8 cadavers (16 sides), 10 cases with frontal defects of knee joints were repaired with island fasciocutaneous flaps which had pedicles of lateral superficial sural artery and the lateral sural nerve.

Results: The anatomical study showed there were three systems of superficial sural blood supply- medial, middle and lateral systems.

[Microsurgical reconstruction of the nasal subunit defects].

Objective: The nose is composed of several delicate subunits, some of which are difficult to reconstruct if they have been injured. The paper presents the microsurgical technique to repair the nasal subunit defects with the free combined preauricular and auricular flap which well match the nasal tissues in texture, contour and color.

Methods: The nasal subunit defects were repaired with the combined preauricular and auricular flap which were vascularized by the superficial temporal vascular system.

[Nasal alar reconstruction with a vascularized free auricular composite flap].

Objective: The plastic surgeons prefer to reconstruct nasal alar with free auricular composite flap because it well matches nasal tissue in contour, texture and color. However, the size of the free composite flap should be less than 1. 0 cm x 1.

[Inhibiting scar formation in rat cutaneous wounds by blocking TGF-beta signaling].

Objective: TGF-beta plays a key role in wound scarring. This study explored the possibility of using gene therapy to inhibit wound scarring by blocking TGF-beta signaling.

Methods: In vitro, human normal dermal fibroblasts were infected with recombinant adenoviruses of truncated TGF-beta receptor II (tTGF-betaRII, 100 pfu/cell) and beta-galactosidase (beta-gal, 100 pfu/cell), and their effects on regulating TGF-beta1 gene expression were analyzed by Northern blot.