Publications by authors named "Dan-Yi Lin"
Background: Antisocial behavior (ASB) infringes on the rights of others and significantly disrupts social order. Studies have shown that ASB is phenotypically associated with various psychiatric disorders. However, these studies often neglected the importance of genetic foundations.
View Article and Find Full Text PDFObjects: Previous studies have suggested a potential correlation between rheumatoid arthritis (RA) and biological aging, but the intricate connections and mechanisms remain elusive.
Methods: In our study, we focused on two specific measures of biological age (PhenoAge and BioAge), which are derived from clinical biomarkers. The residuals of these measures, when compared to chronological age, are defined as biological age accelerations (BAAs).
Background: Sclerostin, a regulator of bone metabolism and vascular calcification involved in regulating the Wnt/β-catenin signaling pathway, has been shown to be involved in the pathogenesis of rheumatoid arthritis (RA). However, current results regarding the circulating sclerostin level of RA patients are debatable. This study aimed to evaluate the circulating level of sclerostin in RA patients and briefly summarize its role.
View Article and Find Full Text PDFThere is a growing body of evidence suggesting an association between air pollution exposure and tuberculosis (TB) incidence, but no meta-analysis has assembled all evidence so far. This review and meta-analysis aimed to derive a more reliable estimation on the association between air pollution and TB incidence. PubMed, Embase and Web of Science electronic databases were systemically searched for eligible literature.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the link between the PER2 gene and systemic lupus erythematosus (SLE), focusing on specific genetic variations (SNPs) that may influence susceptibility to the disease.
- A total of 492 SLE patients and 493 healthy individuals were analyzed using advanced genotyping techniques, revealing significant differences in a particular SNP (rs11894491) between the two groups.
- The findings suggest that variations in the PER2 gene could play a role in both the risk of developing SLE and its clinical symptoms, highlighting its importance in understanding the disease's mechanisms.
Background: Recently, increasing studies have revealed that leptin is involved in the development of rheumatoid arthritis (RA). This study is aimed at exploring the association of gene single nucleotide polymorphisms (SNPs) with susceptibility to RA in a Chinese population.
Methods: We recruited 600 RA patients and 600 healthy controls from a Chinese population and analyzed their three SNPs (rs10244329, rs2071045, and rs2167270) using the improved Multiplex Ligase Detection Reaction (iMLDR) assays.
Air pollution is an important risk factor for autoimmune diseases, but its association with the recurrence of rheumatoid arthritis (RA) remains unclear so far. This study aimed to investigate the short-term association between traffic-related air pollutants and hospital readmissions for RA in Hefei, China. Data on daily hospital readmissions for RA and traffic-related air pollutants, including particulate matter (PM and PM), nitrogen dioxide (NO), and carbon monoxide (CO), from 2014 to 2018 were retrieved.
View Article and Find Full Text PDFBackground: Meteorin-like (Metrnl) is a newly identified adipokine implicated in the pathogenesis of type 2 diabetes mellitus (T2DM), yet data on the circulating levels of Metrnl in patients with T2DM are controversial. To derive a more precise estimation on circulating Metrnl levels in T2DM patients, we conducted this meta-analysis.
Methods: The existing studies on the circulating levels of Metrnl in patients with T2DM published up to 16 January 2020 were comprehensively retrieved from PubMed, Web of Science, EMBASE, and The Cochrane library database.
Circulating adiponectin levels and systemic lupus erythematosus: a two-sample Mendelian randomization study.
Rheumatology (Oxford)
February 2021
Objectives: Several studies have reported increased serum/plasma adiponectin levels in SLE patients. This study was performed to estimate the causal effects of circulating adiponectin levels on SLE.
Methods: We selected nine independent single-nucleotide polymorphisms that were associated with circulating adiponectin levels (P < 5 × 10-8) as instrumental variables from a published genome-wide association study (GWAS) meta-analysis.
Article Synopsis
- The study aimed to investigate the relationship between ambient temperature and hospital admissions for systemic lupus erythematosus (SLE) in Hefei City, China, over a ten-year period.
- Researchers analyzed daily SLE admissions data alongside meteorological data, employing a specific statistical model to account for various factors like seasonality and humidity.
- The results indicated no connection between temperature and first-time admissions, but a significant association was found between low temperatures and increased re-admissions for SLE, suggesting that SLE patients should stay warm to potentially reduce hospital visits.
Mortality and Disease Burden of Injuries from 2008 to 2017 in Anhui Province, China.
Biomed Res Int
February 2021
Objective: To investigate the temporal trends in mortality and disease burden of injuries in Anhui province from 2008 to 2017, so as to provide reference for injury control and prevention.
Methods: Data of mortality were collected from 9 national surveillance points in Anhui province during 2008-2017 in the Information System for Death Cause Register and Management. The surveillance data were analyzed by using crude mortality, standardized mortality rate (SMR), potential year of life lost (PYLL), PYLL rate (PYLLR), and average of year life lost (AYLL).
Article Synopsis
- The study aimed to explore the links between melatonin pathway gene SNPs and the risk of developing systemic lupus erythematosus (SLE) using a cohort of 495 patients and 493 healthy controls.
- Two specific SNPs (rs8150 and rs3760138) were identified as significant; rs8150 lowered SLE risk for certain carriers, while rs3760138 increased the risk for others.
- The findings suggest that melatonin pathway genes may play a role in the susceptibility to SLE and influence specific clinical symptoms, highlighting the importance of further research in this area.
Article Synopsis
- * Results showed that SLE patients had significantly higher PTX3 levels compared to controls, with a pooled effect size indicating this difference.
- * Subgroup analyses revealed that factors like age, ethnicity, disease activity, and sample type influenced PTX3 levels in SLE patients.
Objective: Although patients with psoriasis frequently report seasonal changes in their symptoms, the seasonality of psoriasis has rarely been explored. This study aims to investigate the seasonal pattern of and global public interest in psoriasis using Google search data.
Methods: Internet search data were collected from Google Trends.
Article Synopsis
- - The study investigates the levels of 25-hydroxyvitamin D (25(OH)D) in patients with systemic lupus erythematosus (SLE) to determine its association with SLE risk and severity.
- - A meta-analysis of 19 articles reveals that SLE patients have significantly lower circulating 25(OH)D levels compared to healthy individuals, with certain subgroups (e.g., those with higher disease activity or no vitamin D supplementation) showing more pronounced deficiencies.
- - The analysis indicates that vitamin D status can influence SLE risk, where both deficiency and insufficiency increase SLE risk significantly, while sufficient levels appear to slightly mitigate the risk.
Plasma galectin-3 levels do not differ in systemic lupus erythematosus patients.
Int J Rheum Dis
October 2019
Article Synopsis
- - The study aimed to analyze plasma galectin-3 levels in systemic lupus erythematosus (SLE) patients and compare them with healthy individuals, involving 90 patients and 90 controls of similar age and gender distribution.
- - Results showed no significant differences in galectin-3 levels between SLE patients and controls or among different SLE activity levels and nephritis status, indicating a potential lack of relationship between galectin-3 and these clinical features.
- - Although there was a negative correlation between galectin-3 levels and immune globulin M, overall findings suggest that galectin-3 may not play a significant role in SLE, highlighting the need for further research.
Article Synopsis
- * Melatonin (MLT) has immunomodulatory effects, impacting T cell differentiation and balancing pathogenic Th1/Th17 cells with regulatory T cells, while also regulating the release of inflammatory cytokines.
- * The review emphasizes MLT's potential as a therapeutic target in autoimmune diseases, discussing its influence on key signaling pathways and its capacity to reduce inflammation and cell death in affected tissues.
Factors influencing completion of treatment among pulmonary tuberculosis patients.
Patient Prefer Adherence
April 2019
This study aimed to understand the influencing factors of treatment completion among pulmonary tuberculosis (PTB) patients in Anhui province, eastern People's Republic of China, in order to provide scientific evidence for improving the follow-up rate and treatment completion rate. A total of 262 PTB patients in six counties (districts) of Anhui province were investigated by questionnaire, and data about treatment interruption were collected. The main causes of treatment interruption were forgetting to take medicine (24.
View Article and Find Full Text PDFArticle Synopsis
- * A total of 490 SLE patients and 489 healthy controls were examined for seven specific SNPs of the IL-35 encoding gene to see if there were links to SLE susceptibility and symptoms.
- * Findings revealed that the rs4740 polymorphism is significantly linked to renal and hematological disorders in SLE patients, but no overall associations between the SNPs and SLE risk or plasma IL-35 levels were found.
Autoimmune diseases (ADs) are a broad spectrum of disorders featured by the body's immune responses being directed against its own tissues, resulting in prolonged inflammation and subsequent tissue damage. Recently, the exposure to ambient air pollution has been implicated in the occurrence and development of ADs. Mechanisms linking air pollution exposures and ADs mainly include systemic inflammation, increased oxidative stress, epigenetic modifications induced by exposures and immune response caused by airway damage.
View Article and Find Full Text PDFThis study aims to investigate the global public interest in rheumatoid arthritis by evaluating search term popularity changes of the disease over a decade. Google Trends was applied to retrieve search popularity scores for the term 'rheumatoid arthritis' between January 2004 and December 2017, utilizing the category of "health". Overall, relative searches volume for rheumatoid arthritis steadily decreased from January 2004 to December 2010, and then slowly rose from January 2011 to December 2017.
View Article and Find Full Text PDFRheumatoid arthritis (RA) patients have increased risk of cardiovascular disease (CVD) death. Elevated asymmetric dimethylarginine (ADMA) levels have been reported to be an independent predictor of CVD morbidity and mortality, however, the role of ADMA in RA remains undetermined. To derive a more accurate estimation on circulating ADMA levels in RA patients, a meta-analysis was performed.
View Article and Find Full Text PDFObjectives: Human epidermal growth factor receptor 2 (HER2, ERBB2) is a valuable prognostic and predictive biomarker in breast cancer. Accurate assessment of HER2 status is essential in selecting the patients with invasive breast cancer who will likely response to HER2-targeted therapies. Some major modifications in the diagnostic recommendation for fluorescence in situ hybridization (FISH) have been made in the updated 2018 American Society of Clinical Oncology (ASCO)/College of American Pathologist (CAP) guideline.
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