Publications by authors named "Dan-Yan Ou"
Article Synopsis
- The study aimed to identify genetic mutations in two Chinese children with dysfibrinogenemia and analyze their families.
- Genetic analysis of fibrinogen genes (FGA, FGB, FGG) was performed using PCR and direct sequencing, along with plasma analysis through western blotting and electron microscopy.
- Proband 1 had a specific mutation (Arg275Cys) linked to symptoms, while Proband 2 showed very low functional fibrinogen with no identifiable mutations, suggesting other mechanisms beyond genetic mutations might cause their condition.
[Association of CCR2 gene rs1799864 polymorphism with hemophagocytic lymphohistiocytosis in children].
Zhongguo Dang Dai Er Ke Za Zhi
February 2015
Article Synopsis
- The study aimed to explore the relationship between a specific genetic variation (rs1799864 SNP) in the CCR2 gene and the risk of hemophagocytic lymphohistiocytosis (HLH) in children.
- Researchers analyzed data from 86 children diagnosed with HLH and compared it to 128 healthy controls, finding no significant differences in the genetic variation between the two groups.
- Although the genetic polymorphism didn't correlate with HLH susceptibility, it was linked to differences in age of onset and recovery durations of certain symptoms after treatment.
CD20 and Outcome of Childhood Precursor B-cell Acute Lymphoblastic Leukemia: A Meta-analysis.
J Pediatr Hematol Oncol
April 2015
CD20 is a B-cell differentiation antigen that is expressed variably in precursor B-cell acute lymphoblastic leukemia (BCP-ALL). The prognostic significance of CD20 expression in childhood BCP-ALL remains controversial. Some studies have demonstrated that CD20 overexpression correlates with worse survival in pediatric patients with BCP-ALL, but some other studies suggest a better outcome.
View Article and Find Full Text PDF[XIAP gene mutation screening in children with hemophagocytic lymphohistiocytosis].
Zhongguo Dang Dai Er Ke Za Zhi
March 2014
Objective: To investigate the prevalence of mutations and sequence variations in X-linked inhibitor of apoptosis (XIAP) gene among Chinese pediatric patients with hemophagocytic lymphohistiocytosis (HLH).
Methods: Sixty-five children who were diagnosed with HLH between January 2009 and December 2012 (case group), as well as 70 healthy children (control group), were enrolled in the study. The exons of XIAP gene (1-1, 1-2, 2-6) were amplified by PCR and directly sequenced.