: The causal association of specific gut microbiota with dementia remains incompletely understood. We aimed to access the causal relationships in which one or more gut microbiota account for dementia. : Using data from the MiBioGen and FinnGen consortia, we employed multiple Mendelian randomization (MR) approaches including two-sample MR (TSMR), multivariable MR (MVMR), and Bayesian model averaging MR to comprehensively evaluate the causal associations between 119 genera and dementia, and to prioritize the predominant bacterium.
View Article and Find Full Text PDFThe causal association of circulating metabolites with dementia remains uncertain. We assessed the causal association of circulating metabolites with dementia utilizing Mendelian randomization (MR) methods. We performed univariable MR analysis to evaluate the associations of 486 metabolites with dementia, Alzheimer's disease (AD), and vascular dementia (VaD) risk.
View Article and Find Full Text PDFImportance: Epidemiological evidences regarding the association between whole grain intake and the risk of new-onset hypertension are still controversial.
Objective: We aimed to investigate the relationship between whole grain intake and new-onset hypertension and examine possible effect modifiers in the general population.
Methods: A total of 10,973 participants without hypertension from the China Health and Nutrition Survey were enrolled, with follow-up beginning in 1997 and ending in 2015.
Ambient air pollution is a major global health concern. Yet, no study has thoroughly assessed its link to respiratory mortality. Our research evaluated the combined and individual effects of air pollutants on respiratory mortality risks based on the UK Biobank.
View Article and Find Full Text PDFEcotoxicol Environ Saf
March 2024
Backgrounds: Short-term exposure to air pollutants increases the risk of migraine, but the long-term impacts of exposure to multiple pollutants on migraine have not been established. The aim of this large prospective cohort study was to explore these links.
Methods: A total of 458,664 participants who were free of migraine at baseline from the UK Biobank were studied.
Background: The relationship between whole grain intake and chronic kidney disease (CKD) remains uncertain.
Objective: This study aimed to evaluate the association between whole grain intake and risk of CKD in Chinese adults.
Methods: The present cross-sectional study used data from the China Health and Nutrition Survey conducted in 2009.