Publications by authors named "Dan-Qi Liu"
Background: Diminished ovarian reserve (DOR) is a danger signal of reduced fertility. The clinical incidence is increasing yearly, exhibiting a gradual low-age trend. Traditional Chinese medicine theory suggests that kidney deficiency is the basic pathogenesis.
View Article and Find Full Text PDFObjective: To evaluate the effect of electro-acupuncture (EA) in infertile patients with phlegm-dampness polycystic ovary syndrome-insulin resistance (PCOS-IR).
Methods: Seventy-six PCOS-IR patients who underwnet in vitro fertilization and embryo transfer (IVF-ET) were equally assigned to two groups according to a random digital table: the EA group and the control group, with 38 cases in each group. Before undergoing IVF, the two groups were treated with EA or pseudo-acupuncture, respectively, for 3 menstrual cycles.
Article Synopsis
- The study investigates the genetic factors affecting the metabolism and transport of the anti-epileptic drug oxcarbazepine (OXC) in Chinese patients, focusing on specific genes: CYP3A4, CYP3A5, and ABCB1.
- It involved 66 patients, with some on OXC alone while others were on combination therapies with other anti-epileptic drugs like lamotrigine, levetiracetam, or valproic acid.
- Results showed significant genetic associations with drug plasma concentrations only in the group receiving OXC and valproic acid, suggesting that genetic variations may not significantly influence OXC metabolism in monotherapy or other combinations.
Objective: To examine the effects of cytochrome P450 3A4 (CYP3A4), cytochrome P450 3A5 (CYP3A5) and ATP-binding cassette sub-family B member 1 (ABCB1) genetic polymorphisms on carbamazepine (CBZ) plasma concentrations in Chinese patients with epilepsy using CBZ as monotherapy and bitherapy with phenytoin (PHT), phenobarbital (PB), or valproic acid (VPA).
Methods: Eighty-eight Chinese patients with epilepsy were recruited from Xiangya Hospital Central South University, of whom 66 patients were placed in the CBZ monotherapy group, 10 patients were placed in the CBZ bitherapy group combined with one enzyme-inducing anti-seizure medications (PHT or PB), and 12 patients were placed in the CBZ bitherapy group combined with VPA. Carbamazepine and carbamazepine-10,11-epoxide (CBZ-E) plasma concentration of these patients were measured.