Publications by authors named "Dan-Pei Li"
Article Synopsis
- Beige fat activation shifts energy use to fatty acid oxidation after chronic cold exposure, involving a protein called ACSL1 located in mitochondria.
- Sortilin is an endosomal trafficking component that helps direct ACSL1 for degradation, affecting its levels in adipose tissues during beige fat activation.
- Lowering sortilin in fat cells raises mitochondrial ACSL1, boosts AMPK/PGC1α signaling, enhances beige fat activation, and may help combat obesity and insulin resistance linked to high-fat diets.
Inhibition of immunocyte infiltration and activation has been suggested to effectively ameliorate nonalcoholic steatohepatitis (NASH). Paired immunoglobulin-like receptor B (PirB) and its human ortholog receptor, leukocyte immunoglobulin-like receptor B (LILRB2), are immune-inhibitory receptors. However, their role in NASH pathogenesis is still unclear.
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