Publications by authors named "Dan-Jing Wan"
Article Synopsis
- HLP, a new thrombin peptide inhibitor, effectively reduces neointimal formation in rat and rabbit models, showing promise for vascular injury treatment.
- Pharmacokinetic analysis in Sprague-Dawley rats revealed a half-life of HLP between 25 and 31 minutes and that it primarily accumulates in the kidneys and stomachs.
- Continuous infusion of HLP did not significantly alter vital signs, but it extended bleeding time and reduced ADP-induced platelet aggregation, indicating it has anticoagulant properties without major side effects.
Aim: To investigate the body distribution in mice of [14C]-labeled poly methoxyethyleneglycol cyanoacrylate-co-n-hexadecyl cyanoacrylate (PEG-PHDCA) nanoparticles and in situ evading of phagocytic uptake by mouse peritoneal macrophages.
Methods: PEG-PHDCA copolymers were synthesized by condensation of methoxypolyethylene glycol cyanoacetate with [14C]-hexadecyl-cyanoacetate. [14C]-nanoparticles were prepared using the nanoprecipitation/solvent diffusion method, while fluorescent nanoparticles were prepared by incorporating rhodamine B.