A high-sensitivity continuous glucose sensor using porous 3D cellulose/ carbon nanotube network.

While numerous needle-based continuous glucose monitoring (CGM) devices have been available today, the insufficient enzyme immobilization on monitoring sensor severely limited the detection sensitivity of CGM devices. This manuscript describes here a high-sensitivity continuous glucose sensor (CGS) by engineering a porous 3D cellulose/carbon nanotube (CNT) network on the working electrode, which subcutaneously increases the detection enzyme capacity and thus significantly enhances the signal intensity and sensitivity. Furthermore, a tapered needle made of soft resin is engraved into three distinct microgrooves where the glucose oxidase (GOD)-modified working electrode, Pt-modified counter electrode, and Ag/AgCl-modified reference electrode are separately constructed inside the microgrooves.

Noncoding RNAs in doxorubicin-induced cardiotoxicity and their potential as biomarkers and therapeutic targets.

Anthracyclines, such as doxorubicin (DOX), are well known for their high efficacy in treating multiple cancers, but their clinical usage is limited due to their potential to induce fatal cardiotoxicity. Such detrimental effects significantly impact the overall physical condition or even induce the morbidity and mortality of cancer survivors. Therefore, it is extremely important to understand the mechanisms of DOX-induced cardiotoxicity to develop methods for the early detection of cytotoxicity and therapeutic applications.

Exenatide Protects Against Cardiac Dysfunction by Attenuating Oxidative Stress in the Diabetic Mouse Heart.

Cardiovascular disease is the major cause of death in patients with diabetes. Current treatment strategies for diabetes rely on lifestyle changes and glucose control to prevent angiopathy and organ failure. Exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist, is used as an add-on therapy to insulin treatment.