Publications by authors named "Dan Zyc"
Article Synopsis
- The endocannabinoid system, specifically CB2, plays a complex role in colon cancer, with evidence suggesting it may influence immune responses.
- In experiments with mice, those lacking CB2 exhibited a higher occurrence of precancerous lesions and increased tumor development, alongside changes in immune cell populations.
- Analysis of human genomic data indicates a link between specific variants and colon cancer incidence, highlighting the potential for CB2 as a target for cancer prognosis and treatment.
Erythropoietin (EPO) is a pleiotropic cytokine that classically drives erythropoiesis but can also induce bone loss by decreasing bone formation and increasing resorption. Deletion of the EPO receptor (EPOR) on osteoblasts or B cells partially mitigates the skeletal effects of EPO, thereby implicating a contribution by EPOR on other cell lineages. This study was designed to define the role of monocyte EPOR in EPO-mediated bone loss, by using two mouse lines with conditional deletion of EPOR in the monocytic lineage.
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