Packing Engineering of Zirconium Metal-Organic Cages in Mixed Matrix Membranes for CO2/CH4 Separation.

Metal-organic cages (MOCs) have been considered as emerging zero-dimensional (0D) porous fillers to generate molecularly homogenous MOC-based membrane materials. However, the discontinuous pore connectivity and low filler concentrations limit the improvement of membrane separation performance. Herein, we propose the dimension augmentation of MOCs in membranes using three-dimensional (3D) supramolecular MOC networks as filler materials in mixed matrix membranes (MMMs).

Chlorogenic Acid: A Promising Strategy for Milk Preservation by Inhibiting Growth and Biofilm Formation.

Chlorogenic acid (CGA), a polyhydroxy phenolic acid, has been extensively studied for its antimicrobial properties. () threatens food safety by forming biofilms. This study aimed to investigate the mechanism of CGA against and its biofilm.

Nanospace Engineering for C Aromatic Isomer Separation.

C aromatic isomers, namely para-xylene (PX), meta-xylene (MX), ortho-xylene (OX), and ethylbenzene (EB), are essential industrial chemicals with a wide range of applications. The effective separation of these isomers is crucial across various sectors, including petrochemicals, pharmaceuticals, and polymer manufacturing. Traditional separation methods, such as distillation and solvent extraction, are energy-intensive.

FcRn-guided antigen trafficking enhances cancer vaccine efficacy.

The development of tumor vaccines represents a significant focus within cancer therapeutics research. Nonetheless, the efficiency of antigen presentation in tumor vaccine remains suboptimal. We introduce an innovative mRNA-lipid nanoparticle platform designed to express tumor antigenic epitopes fused with the transmembrane domain and cytoplasmic tail of the neonatal Fc receptor (FcRn).

Advanced Catalysts for the Chemical Recycling of Plastic Waste.

Plastic products bring convenience to various aspects of the daily lives due to their lightweight, durability and versatility, but the massive accumulation of post-consumer plastic waste is posing significant environmental challenges. Catalytic methods can effectively convert plastic waste into value-added feedstocks, with catalysts playing an important role in regulating the yield and selectivity of products. This review explores the latest advancements in advanced catalysts applied in thermal catalysis, microwave-assisted catalysis, photocatalysis, electrocatalysis, and enzymatic catalysis reaction systems for the chemical recycling of plastic waste into valuable feedstocks.

Direct Synthesis of Topology-Controlled BODIPY and CO2-Based Zirconium Metal-Organic Frameworks for Efficient Photocatalytic CO2 Reduction.

Boron dipyrromethene (BODIPY)-based zirconium metal-organic frameworks (Zr-MOFs) possess strong light-harvesting capabilities and great potential for artificial photosynthesis without the use of sacrificial reagents. However, their direct preparation has not yet been achieved due to challenges in synthesizing suitable ligands. Herein, we reported the first successful direct synthesis of BODIPY-based Zr-MOFs, utilizing CO₂ as a feedstock.

Enhanced healing of MRSA-infected wounds with okara cellulose nanocrystals-based temperature-sensitive cationic hydrogel: Development and characterization.

The development of functional hydrogel dressings with robust mechanical properties has posed a significant challenge in expediting the healing process of MRSA-infected wounds. To address this, a composite hydrogel, comprising carboxylated soybean cellulose nanocrystals (CNCs), poly(N-isopropyl acrylamide) (PNIPAM), dimethyl diallyl ammonium chloride (PDADMAC), and kaolin (CN/P-K) was synthesized. CNCs served to stabilize the interpenetrating polymer networks of PNIPAM and PDADMAC through hydrogen bonding and electrostatic interactions, respectively, while the kaolin interlayer improved the material toughness.

The Malectin-like kinase gene MdMDS1 negatively regulates the resistance of Pyrus betulifolia to Valsa canker by promoting the expression of PbePME1.

Valsa canker, caused by fungal pathogens in Valsa species, is a fungal disease of apple and pear growing in China and even in Asia. Malectin-like kinases play crucial roles in plant recognition of the pathogen-induced signals and subsequent activation of partially host immune responses. However, the role of MEDOS1 (MDS1), a Malectin-like kinase, in plant immunity has not yet been extensively explored.

Gender difference in the association between volunteering and health-related quality of life among hearing-impaired older adults in China.

Background: The present study aims to assess the relationship between volunteering and health-related quality of life (HRQoL) among older adults with hearing impairment, as well as the gender difference in this association.

Methods: We use data from the sixth Health Service Survey of Shandong Province, China. The survey interviewed 35,264 respondents, from which a total of 1,457 hearing-impaired older adults were included in the study.

Synergistic Effect and Mechanism of Combined Astaxanthin and Curcumin Administration on Ovarian Function in PCOS Mice.

To investigate the synergistic effect of astaxanthin and curcumin on ovarian function in polycystic ovary syndrome (PCOS) mice and to elucidate the underlying mechanisms, fifty 4-week-old female mice were randomly divided into five groups: (i) normal control group; (ii) PCOS model group; (iii) PCOS + astaxanthin group; (iv) PCOS + curcumin group; and (v) PCOS + astaxanthin-curcumin. Throughout the study, various parameters were meticulously evaluated, including serum levels of key reproductive hormones (testosterone (T), estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and anti-Müllerian hormone (AMH)), as well as monitoring alterations in the estrous cycle, follicle development, and ovulation rates. Additionally, markers of oxidative stress and inflammation were measured.

Left ventricular wall thickness discrepancies at end-diastole and mid-diastole: Reference values for cardiac CT.

Purpose: To investigate differences in left ventricular wall thickness (LVWT) measurements between end-diastole and mid-diastole using cardiac computed tomography (CCT) and establish LVWT reference values stratified by phase, sex, and region.

Methods: Subjects who underwent CCT without a history of cardiovascular disease or risk factors were retrospectively included between 2021 and 2024. LVWT was manually measured in each segment according to the American Heart Association's 17-segment model at end-diastole and mid-diastole.

Signing contracts for family doctors, functional limitations and home care willingness among older adults: a cross-sectional study.

Background: Traditional Chinese culture advocates home care be provided by family members. Home care can improve mental health and enjoy a familiar environment for older people. This study aimed to investigate the relationship between signing contracts for family doctors and home care willingness, as well as the interaction effect of functional limitations in this relationship.

Comparative analysis of antioxidant activity and structural changes of polysaccharides between sulfur-fumigation and nonsulfur-fumigation.

Introduction: (referred to Tianma in Chinese), the dried tuber of Bl. (Orchidaceae), is utilized as a medicine-food homology product. Sulfur fumigation is commonly employed in the processing of (GR).

Hypoxic mesenchymal stem cell-derived exosomal circDennd2a regulates granulosa cell glycolysis by interacting with LDHA.

Background: Premature ovarian insufficiency (POI) is an ovarian dysfunction disorder that significantly impacts female fertility. Ovarian granulosa cells (GCs) are crucial somatic components supporting oocyte development that rely on glycolysis for energy production, which is essential for follicular growth. Hypoxia-induced exosomal circRNAs regulate glycolysis, but their biological functions and molecular mechanisms in POI are largely unexplored.

Solvent-responsive covalent organic framework membranes for precise and tunable molecular sieving.

Membrane-based nanofiltration has the potential to revolutionize the large-scale treatment of organic solvents in various applications. However, the widely used commercial membranes suffer from low permeability, narrow structural tunability, and limited chemical resistance. Here, we report a strategy for fabricating covalent organic framework (COF) membranes with solvent-responsive structural flexibility.

Long-Term Stable Reference Electrodes with High-Pressure Tolerance and Salinity-Independence.

The reference electrode's performance is essential for ensuring the accuracy of electrochemical sensors in marine environments. Yet, the many existing reference electrodes can exhibit sensitivity to salinity variations, potentially leading to inaccuracies in the measurement process. Herein, we have designed a reliable solid-state reference electrode by introducing SiO-stabilized 1-methyl-3-octylimidazolium bis(trifluoromethyl sulfonyl)imide ([Cmim] [Ntf]) into a P(VdF--HFP) matrix with a SPEEK/[Cmim] [Ntf] coated Ag/AgCl as substrate.

Ionic Thermoelectric-Powered Resistive Sensors.

Ionic thermoelectric supercapacitors (ITESCs) are noted for their high ionic Seebeck coefficient (α) to convert thermal energy into electrical current through charging. This work demonstrates the utilization of the charging and discharging current from ITESCs to directly operate resistive sensors. The humidity monitoring is powered by applying a periodic temperature gradient to a connected ITESC.

Identification of TUBB3 as an immunotherapy target in lung cancer by genome wide in vivo CRISPR screening.

Recent development of immune checkpoint inhibitors has revolutionized cancer immunotherapy. Although these drugs show dramatic effects on a subset of cancer patients, many other tumors are non-responsive and the pathological mechanism of the resistance is largely unknown. To identify genes underlying anti-PD-1 immunotherapy resistance using a systematic approach, we performed an in vivo genome wide CRISPR screening in lung cancer cells.

Evolving Emulsion Microcompartments via Enzyme-Mimicking Amyloid-Mediated Interfacial Catalysis.

Living organisms take in matter and energy from their surroundings, transforming these inputs into forms that cells can use to sustain metabolism and power various functions. A significant advancement in the development of protocells and life-like materials has been the creation of cell-like microcompartments capable of evolving into higher-order structures characterized by hierarchy and complexity. In this study, a smart emulsion system is designed to digests chemical substrates and generates organic or inorganic products, driving the self-organization and structuration of microcompartments.

Changing trends in lung cancer disease burden between China and Australia from 1990 to 2019 and its predictions.

Purpose: Lung cancer (LC) is a leading cause of death and presents a substantial societal burden. This article compares its disease burden and risk factors between China and Australia to support health policymakers for LC prevention and treatment.

Materials And Methods: The data from the 2019 Global Burden of Disease Study were used to analyze disease temporal trends using Joinpoint regression model.

Ostracod-based transfer function shifting to a broad prospect in palaeolimnology and palaeoclimate.

The ostracod-based transfer function is a common method in palaeolimnology and palaeoclimate research, serving as an interpreter from fossil record to palaeoenvironment history. However, migration application of the transfer function remains challenging, and it is characterized by the use of the threshold of the transfer function and restriction of the understanding of palaeolimnology and palaeoclimate. Here, we constructed transfer functions for water salinity, alkalinity, and Ca conditions employing ecological information about four key species in the Yamdrok-tso basin.

Correlation between gestational diabetes mellitus and postpartum cardiovascular metabolic indicators and inflammatory factors: a cohort study of Chinese population.

Objective: This study aimed to analyze the correlation between gestational diabetes mellitus and postpartum metabolic indicators and inflammatory factors, and explore the role of inflammatory factors, so as to provide evidence for the early prevention of postpartum CVD risk in gestational diabetes mellitus.

Methods: This prospective study was based on the pregnant women cohort study established in Peking University International Hospital from December 2017 to March 2019. A total of 120 women were enrolled sequentially, including 60 cases of gestational diabetes mellitus (GDM group) and 60 cases of non-gestational diabetes mellitus (non-GDM group) after 4-7 years.