Gastric ulcers (GC) are prevalent gastrointestinal disorders with complex etiologies, including Helicobacter pylori infection and prolonged use of non-steroidal anti-inflammatory drugs (NSAIDs). Curcumin (CUR), with its established anti-inflammatory and antioxidant properties, is limited in clinical application due to poor bioavailability. This study developed oleanolic acid-coated CUR nanoparticles (OC NPs) to enhance the efficacy of CUR in GC prevention.
View Article and Find Full Text PDFBackground: Many studies have reported the important role of glucagon-like peptide-1 receptor (GLP-1R) in regulating glucose homeostasis. However, in addition to the pancreas, GLP-1R is distributed in organs such as the lungs. A few researches have reported the mechanism of action of GLP-1R in acute and chronic lung diseases.
View Article and Find Full Text PDFHerein, a superhydrophobic surface was designed and fabricated based on the "lotus effect" construction mechanism. The zeolitic imidazolate framework (ZIF-90) micro-nanoparticles were initially synthesized via a one-pot method, combined with long-chain stearic acid (STA), and subsequently embedded in polyvinyl butyral (PVB) to form a superhydrophobic surface at room temperature. The superhydrophobic surface demonstrated mechanical stability and retained its superhydrophobicity with a water contact angle (CA) greater than 150°, even at a wear distance of 400 cm.
View Article and Find Full Text PDFBackground: Neurosyphilis results from invading the central nervous system, leading to severe neurological issues like stroke. Combining hyperbaric oxygen (HBO) therapy and transcranial ultrasound neuromuscular stimulation (TUS-NMES) shows promise in improving outcomes.
Objective: This study evaluates the predictive value and clinical significance of CXCL13, WBC, and Hs-CRP levels in neurosyphilis patients undergoing HBO and TUS-NMES therapy.
The increasing impacts of climate change and intensified human activities exacerbate soil salinization, posing significant challenges to agricultural productivity. Therefore, addressing salt stress in crops is a critical area of research. In this study, strawberry seedlings (Fragaria×ananassa Duch.
View Article and Find Full Text PDFThe phenomenon of multiple-grain spikelets is frequently observed in gramineous crops. In the case of dual-floret spikelets, the upper fertile floret develops normally to form a single grain, while the lower sterile floret undergoes abortion. Here we elucidate the role of Double-Grain 1 (DG1), a gene encoding a homeobox-domain-containing protein, in regulating the lower floret meristem activity and double-grain spikelet trait in sorghum.
View Article and Find Full Text PDFVentricular arrhythmias associated with cardiac adrenergic stress and hypertrophy pose a significant clinical challenge. We explored ventricular anti-arrhythmic effects of P21-activated kinase 2 (Pak2), comparing in vivo and ex vivo cardiomyocyte-specific Pak2 knockout (Pak2) or overexpression (Pak2) murine models, under conditions of acute adrenergic stress, and hypertrophy following chronic transverse aortic constriction (TAC). Pak2 was downregulated 5 weeks following the latter TAC challenge.
View Article and Find Full Text PDFIn this study, the biological applications of cultivation methods related to cultivar selection, vegetative growth, and reproductive development in Lentinula edodes cultivation are briefly reviewed to clarify the current situation and inform future developments. The current cultivars widely used in the main production areas are derived from wild strains distributed in northern Asia. The most effective techniques for cultivar identification are molecular markers identified in two nuclear genome datasets and one mitochondrial genome dataset.
View Article and Find Full Text PDFIntelligent Transportation Systems (ITSs) have become pivotal in urban traffic management by utilizing traffic flow prediction, which aids in alleviating congestion and facilitating route planning. This study introduces the Linear Attention Based Spatial-Temporal Multi-Graph Convolutional Neural Network (LASTGCN), a novel deep learning model tailored for traffic flow prediction. LASTGCN incorporates a Multifactor Fusion Unit (MFF-unit) to dynamically integrate meteorological factors, an advanced multi-graph convolutional network for spatial correlations, and the Receptance Weighted Key Value (RWKV) block, which employs a linear attention mechanism for efficient processing of historical traffic data.
View Article and Find Full Text PDFLung cancer, a leading cause of cancer-related mortality globally, presents complex challenges in treatment and disease management. This review explores β-elemene, a sesquiterpene from Curcuma wenyujin, emphasising its pharmacological effects and therapeutic mechanisms in lung cancer. Focusing on its roles in modulating cellular pathways, this study details β-elemene's influence on apoptosis, autophagy, ferroptosis, hypoxic responses, metabolic shifts, and cell cycle arrest, as well as its impact on the tumour microenvironment and regulatory pathways (including PI3K/AKT, STAT3, AMPK/MAPK) and non-coding RNAs.
View Article and Find Full Text PDFSorghum, the fifth most important food crop globally, serves not only as a source of silage forage, fiber, syrup, and biofuel, but also is widely recognized as an ideal model crop for studying stress biology due to its exceptional ability to tolerate multiple abiotic stresses, including high salt-alkali conditions, drought, and heat. However, conducting functional genomics studies on sorghum has been challenging, primarily due to the limited availability of genetic resources and effective genetic transformation techniques. In this study, we developed a comprehensive and systematic resource platform (https://sorghum.
View Article and Find Full Text PDFBackground: Women are particularly vulnerable to depression during pregnancy, which is one of the strongest risk factors for developing postpartum depression (PPD). Addressing antenatal depressive symptoms in these women is crucial for preventing PPD. However, little is known about the effectiveness of internet-based cognitive behavioral therapy (ICBT) in preventing PPD in this high-risk group.
View Article and Find Full Text PDFIEEE Trans Neural Netw Learn Syst
March 2025
Broad learning system (BLS) have demonstrated excellent performance in terms of both speed and accuracy in tasks such as image classification. In BLS, the feature nodes predominantly utilize linear features, and sparse representation is mainly employed in the feature optimization component. The robustness of these features to different data needs to be improved.
View Article and Find Full Text PDFPurpose: This study investigated the proteomic landscape of exfoliation glaucoma to find potential biomarkers.
Methods: The study enrolled 34 patients diagnosed with either exfoliation syndrome with/without glaucoma or age-related cataract. Plasma proteins were analyzed through mass spectrometry and Mendelian randomization (MR) based on data from deCODE, FinnGen, Atherosclerosis Risk in Communities (ARIC), eQTLGen, and UK Biobank (UKB) cohorts to infer relationships.
Recently, rechargeable calcium-ion batteries (CIB) have been investigated extensively due to their safety, environmental friendliness, abundant storage capacity, low cost, and their energy density and power density characteristics. This paper presents a systematic review of recent research advancements in anode materials, including alloys, organic materials, carbon-based materials, and transition metal oxide. First, the basic properties of CIBs and the challenges associated with anode materials are described.
View Article and Find Full Text PDFBackground: In late 2023, the first human case caused by an H10N5 avian influenza virus (AIV) was diagnosed in China. H10Ny AIVs have been identified in various poultry and wild birds in Eurasia, the Americas, and Oceania.
Methods: We analyzed the clinical data of the H10N5 AIV-infected patient, isolated the virus, and evaluated the virus receptor-binding properties together with the H10N8 and H10N3 AIVs identified in humans and poultry.
Background: Enhanced Recovery After Surgery (ERAS) protocols have revolutionized postoperative care, particularly in minimally invasive spine surgery (MISS). This study aims to evaluate the role of nursing interventions in improving patient outcomes and reducing healthcare costs within this framework.
Methods: This retrospective cohort study evaluated 150 patients undergoing MISS at The First Affiliated Hospital of Guangzhou University of Chinese Medicine from January 2017 to December 2021.
ACS Appl Mater Interfaces
March 2025
Electrolysis of water represents an effective method for the generation of high-purity hydrogen. Nevertheless, the anodic oxygen evolution reaction (OER) exhibits slow kinetics, which leads to a high electrolytic potential and induces excessive energy consumption. In this work, nickel foam-supported 3D phosphide/bimetal nitride (CoP-NiMoN/NF) nanorod array catalyst is prepared by calcination of NiMoO, followed by phosphatization of Co(OH).
View Article and Find Full Text PDFThe HLA-A*31:01:58 allele differs from HLA-A*31:01:02:01 by one nucleotide substitution in codon 130 in exon 3.
View Article and Find Full Text PDFIEEE Trans Med Imaging
February 2025
Cerebrovascular diseases (CVDs) remain a leading cause of global disability and mortality. Digital Subtraction Angiography (DSA) sequences, recognized as the gold standard for diagnosing CVDs, can clearly visualize the dynamic flow and reveal pathological conditions within the cerebrovasculature. Therefore, precise segmentation of cerebral arteries (CAs) and classification between their main trunks and branches are crucial for physicians to accurately quantify diseases.
View Article and Find Full Text PDFThe adaptive event-triggered control problem for a class of uncertain high-order pure feedback nonlinear systems (HOPFNSs) is considered. Different from the traditional backstepping method, a new high-order backstepping method is proposed based on the high-order fully actuated (HOFA) system approaches to design the adaptive event-triggered control law, which has the significant advantages of simple structure, high degree of freedom, and easy to realize. The high-order backstepping method does not need to transform the HOPFNSs into the first-order systems, which is more efficient and significantly reduces design complexity.
View Article and Find Full Text PDFIEEE Trans Neural Netw Learn Syst
January 2025
In the case of label space alignment, the existing domain adaptation (DA)-based fault diagnosis approaches have achieved high accuracy. In real industrial scenarios, however, the label space of the target domain is usually a subset of the label space of the source domain, called partial DA (PDA). The main challenge of PDA lies in how to separate common samples from private samples.
View Article and Find Full Text PDFOptical Coherence Tomography (OCT) imaging is extensively utilized for non-invasive observation of pathological conditions, such as retinal fluid-associated diseases. Accurate fluid segmentation in OCT images is therefore critical for quantifying disease severity and aiding clinical decision-making. However, achieving precise segmentation remains challenging due to pathological variations in shape and size, uncertain boundaries, and low contrast of fluid.
View Article and Find Full Text PDFLung cancer, characterized by its high morbidity and mortality rates, has the capability to metastasize to various organs, thereby amplifying its detrimental impact and fatality. The metastasis of lung cancer is a complex biological phenomenon involving numerous physiological transformations. Exosomes, small membranous vesicles enriched with biologically active components, are pivotal in mediating intercellular communication and regulating physiological functions due to their specificity and stability.
View Article and Find Full Text PDF