Development of Vibrio parahaemolyticus sensitive and specific loop-mediated isothermal amplification combined with lateral flow device.

Background And Aim: Vibrio parahaemolyticus a gram-negative, rod-shaped bacterium with salinophilic properties is found mainly in rivers, oceans, and coastal environments. With the expanding scale of aquaculture in coastal regions of China, the contamination of seafoods with Vibrio parahaemolyticus is becoming a significant cause of food poisoning with symptoms including gastroenteritis, wound infection and sepsis. Current methods for detecting this microorganism are unsuitable in the present context.

Unraveling the Causal Relationship Between Blood Metabolites and Acne: A Metabolomic Mendelian Randomization Study.

Background: Acne is a common skin disorder that may be linked to metabolic dysfunction. However, the causal impact of blood metabolites on acne has not been thoroughly investigated.

Methods: We performed a metabolome-wide Mendelian randomization (MR) analysis on 486 blood metabolites and acne using a genome-wide association dataset.

Fabrication of injectable, adhesive, self-healing, superabsorbent hydrogels based on quaternary ammonium chitosan and oxidized pullulan.

Injectable hydrogels, which are polymeric materials that are characterized by their ability to be injected in a liquid form into cavities and subsequently undergo in situ solidification, have garnered significant attention. These materials are extensively used in a range of biomedical applications. This study synthesized several injectable composite hydrogels through the mild Schiff base reaction while imposing different concentrations of quaternary ammonium chitosan and oxidized pullulan.

Nrf2 dictates the neuronal survival and differentiation of embryonic zebrafish harboring compromised alanyl-tRNA synthetase.

tRNA synthetase deficiency leads to unfolded protein responses in neuronal disorders; however, its function in embryonic neurogenesis remains unclear. This study identified an aars1cq71/cq71 mutant zebrafish allele that showed increased neuronal apoptosis and compromised neurogenesis. aars1 transcripts were highly expressed in primary neural progenitor cells, and their aberration resulted in protein overloading and activated Perk.

Relationship between degree of breast MRI background parenchymal enhancement and breast cancer subtype.

Objectives: To observe the distribution of magnetic resonance imaging (MRI) breast parenchymal enhancement (BPE) among different breast cancer subtypes and to explore the relationship between the BPE and the breast cancer tumor type.

Methods: A total of 150 consecutive patients with breast cancer underwent breast dynamic enhanced scanning image. According to the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2) and Ki-67, the molecular subtypes were classified into Luminal-A, Luminal-B, HER-2 over- expression, and triple-negative breast cancer.

Facile Approach for Synthesizing High-Performance MnO/C Electrodes from Rice Husk.

Pyrolysis is an effective way to convert biomass into biofuel while obtaining highly porous active carbon materials. In this study, a facile approach, involving hydrothermal and pyrolysis steps, is described for preparing hybrid metal oxide nanoparticle-embedded porous hard carbon matrices (MnO/C) from the biowaste rice husk and organometallic precursors. It was found that the pyrolysis/calcination temperature had a strong influence over the microstructure, especially over the porosity, but also over the carbon content and crystallinity of the nanocomposites; hence, the electrical properties can be controlled.

Hierarchical ZnO Superstructures: Nanoflake-Decorated Nanonail Arrays.

By using metallic Zn powders as zinc source, we synthesized unusual hierarchical ZnO superstructures, nanoflake-decorated nanonail arrays, on a large scale via a simple low-temperature thermal evaporation method. The hierarchical superstructures were characterized by using X-ray diffraction, scanning electron microscopy, energy dispersive X-ray spectroscopy, high resolution transmission electron microscopy as well as selected area electron diffraction. Studies found that both the ZnO nanonails and the decorated ZnO nanoflakes are single-crystals, with the preferred growth orientations along the (001) direction.

Experimental and numerical characterization of floc morphology: role of changing hydraulic retention time under flocculation mechanisms.

The formation, breakage, and re-growth of flocs were investigated by using modified flocculation tests and numerical simulation to explore the evolution of floc morphology for different hydraulic retention times. The shorter the aggregation time was, the smaller the flocs produced for the same hydraulic conditions were. Another interesting discovery was that broken flocs that formed in shorter aggregation time had the capacity to completely recover, whereas those formed in a longer amount of time had rather worse reversibility of broken flocs.

Synthesis of phenothiazines via ligand-free CuI-catalyzed cascade C-S and C-N coupling of aryl ortho-dihalides and ortho-aminobenzenethiols.

A ligand-free CuI-catalyzed cascade C-S and C-N cross coupling of (hetero)aryl ortho-dihalides and ortho-aminobenzenethiols has been developed, and various phenothiazines were synthesized with excellent regioselectivity. A possible mechanism is proposed for the cascade coupling.

8-Quinolyl 5-(dimethyl-amino)-naphthalene-1-sulfonate.

In the title compound, C(21)H(18)N(2)O(3)S, the dihedral angle between the naphthalene and quinoline ring systems is 55.53 (2)°, and the torsion angle involving the connecting C-S-O-C atoms is 87.60 (3)°.

Dichlorido[tris-(benzimidazol-2-ylmeth-yl)amine]-indium(III) chloride ethanol solvate dihydrate.

In the title complex, [InCl(2)(C(24)H(21)N(7))]Cl·C(2)H(5)OH·2H(2)O, the In(III) ion is coordinated by four N atoms from the tris-(benz-imidazol-2-ylmeth-yl)amine (NTB) ligand and two Cl atoms in a distorted octa-hedral environment. In the crystal structure, inter-molecular N-H⋯O, O-H⋯O, O-H⋯Cl and weak C-H⋯Cl hydrogen bonds connect the cations, anions and solvent mol-ecules into a three-dimensional network. The ethanol solvent mol-ecule is disordered over two sites with refined occupancies of 0.

5-(Dimethyl-ammonio)naphthalene-1-sulfonate dihydrate.

There are two formula units in the asymmetric unit of the title compound, C(12)H(13)NO(3)S·2H(2)O. In the crystal structure, mol-ecules are linked by inter-molecular O-H⋯O, N-H⋯O and weak C-H⋯O hydrogen bonds, forming a three-dimensional network.

[N,N,N',N'-Tetra-kis(benzimidazol-2-yl-meth-yl)ethane-1,2-diamine]copper(II) sulfate monohydrate.

In the title compound, [Cu(C(34)H(32)N(10))]SO(4)·H(2)O, the Cu(II) ion is coordinated by six N atoms of a hexa-dentate N,N,N',N'-tetra-kis(benzimidazol-2-ylmeth-yl)ethane-1,2-diamine (EDTB) ligand, in a distorted octa-hedral environment. In the crystal structure, inter-molecular N-H⋯O and weak C-H⋯O hydrogen bonds connect the cations, anions and water mol-ecules into a three-dimensional network. The O atoms of the anion are disordered over two sites with refined occupancies of 0.

[N,N,N',N'-Tetra-kis(benzimidazol-2-yl-meth-yl)cyclo-hexane-1,2-diamine]-nickel(II) dinitrate dihydrate.

In the title compound, [Ni(C(38)H(38)N(10))](NO(3))(2)·2H(2)O, the Ni(II) ion is located on a crystallographic twofold rotation axis and is in a distorted octa-hedral coordination environment. The crystal structure is stablized by inter-molecular N-H⋯O and C-H⋯O hydrogen bonds, and weak C-H⋯π inter-actions. The O atoms of the unique nitrate ion are disordered over two sites with occupancies of 0.