Older men display elevated levels of senescence-associated exercise-responsive CD28 angiogenic T cells compared with younger men.

Aging is associated with elevated cardiovascular disease risk. As a result of aging, endothelial dysfunction develops, partly due to a reduction in vascular regenerative ability. CD31 T cells (angiogenic T cells; T ) possess highly angiogenic capabilities; however, these cells are significantly reduced in older populations.

Zero-failure option. One Tennessee hospital system benefits from creating a fully replicated set of data archives. Interview by Mark Hagland.

The five-hospital Saint Thomas Health Services, anchored by Middle Tennessee Medical Center in Murfreesboro, Tenn., several years ago became one of the very first multi-hospital systems in the U.S.

Mechanically unfolding the small, topologically simple protein L.

beta-sheet proteins are generally more able to resist mechanical deformation than alpha-helical proteins. Experiments measuring the mechanical resistance of beta-sheet proteins extended by their termini led to the hypothesis that parallel, directly hydrogen-bonded terminal beta-strands provide the greatest mechanical strength. Here we test this hypothesis by measuring the mechanical properties of protein L, a domain with a topology predicted to be mechanically strong, but with no known mechanical function.