Relationship between residual symptoms of depression and self-reported cognitive impairment.

Objective: The present study aimed to investigate the associations between residual symptoms of depression and specific self-reported symptoms in several cognitive domains.

Methods: The study investigated 117 patients with partially or fully remitted major depressive disorder (MDD) after treatment with antidepressant medications.

Results: Fatigue was significantly associated with inability to focus, alertness, and feeling "blue"; low interest and difficulty with concentration were associated with apathy.

Low-dose transdermal testosterone augmentation therapy improves depression severity in women.

Background: Inadequate response to antidepressant monotherapy in women with major depressive disorder is common. Testosterone administration has been shown to be an effective augmentation therapy in depressed hypogonadal men with selective serotonin reuptake inhibitor-resistant depression. However, the effects of low-dose testosterone as augmentation therapy in women with treatment-resistant depression have not been studied.