Dental follicle stem cells in bone regeneration on titanium implants.

Background: We aimed to demonstrate that DF stem cells from impacted molars and canines can be used to improve bone regeneration on titanium implants surfaces. This study highlights the presence of stem cells in DF, their potential to adhere and differentiate into osteoblasts on different types of titanium surfaces.

Results: Isolated cells from the harvested DF tissue from impacted canine/molars, expressed stem cells markers.

Potential of placental-derived human mesenchymal stem cells for osteogenesis and neurogenesis.

Introduction: Placenta can become an attractive source of stem cells due to its known richness in cell number and accessible, non-invasive procedures to harvest them. The purpose of this study focuses on the pluripotecy of placental-derived mesenchymal stem cells through differentiation towards osteogenic and neurogenic lineages.

Materials And Methods: The biological material was represented by populations of human mesenchymal stem cells isolated from chorionic villi (h-CMSCs) and amniotic membranes (h-AMSCs) of full-term placenta.

Stem cells - biological update and cell therapy progress.

In recent years, the advances in stem cell research have suggested that the human body may have a higher plasticity than it was originally expected. Until now, four categories of stem cells were isolated and cultured in vivo: embryonic stem cells, fetal stem cells, adult stem cells and induced pluripotent stem cells (hiPSCs). Although multiple studies were published, several issues concerning the stem cells are still debated, such as: the molecular mechanisms of differentiation, the methods to prevent teratoma formation or the ethical and religious issues regarding especially the embryonic stem cell research.

Human placenta - stem cell source for obtaining pancreatic progenitors.

Objectives: The apparition of sugar diabetes is produced by the decrease of the number and capacity of beta cells to secrete insulin. Cell mass recovery through cell therapy might be one of the solutions for treating this disease. The use of various cell sources of different differentiation grades has been tried over the last years.

Electrically conductive gold-coated collagen nanofibers for placental-derived mesenchymal stem cells enhanced differentiation and proliferation.

Gold-coated collagen nanofibers (GCNFs) were produced by a single-step reduction process and used for the growth and differentiation of human adult stem cells. The nanomaterials were characterized by a number of analytical techniques including electron microscopy and spectroscopy. They were found to be biocompatible and to improve the myocardial and neuronal differentiation process of the mesenchymal stem cells isolated from the placental chorionic component.

Isolation and characterization of hepatic cancer cells with stem-like properties from hepatocellular carcinoma.

Background & Aims: Major burdens in the treatment of hepatocellular carcinoma (HCC) are the high percentage of recurrence and resistance to chemotherapy. Hepatic cancer stem cells provide a reservoir of cells that can self-renew, maintain the tumor by generating differentiated non-stem cells which make up the bulk of the tumor and are responsible for recurrence after ablative surgery and chemoradiotherapy. The objective of this study was to identify and characterize a self-renewing subpopulation of human liver tumor cells with a distinctive genetic profile that adds the capacity to proliferate despite chemotherapy and promotes cancer recurrence.